8 - Methoxy - 1 - Methylisoquinoline

Base Information

• Chemical Name: 8 - Methoxy - 1 - Methylisoquinoline
• CAS No.: 1231948-70-1
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21
• Hs Code.: 2933499090
• Mol file: 1231948-70-1.mol

Synonyms:8-methoxy-1-methyl-isoquinoline;

Chemical Property of 8 - Methoxy - 1 - Methylisoquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 2.55180

Purity/Quality:

98.5% ^*data from raw suppliers

8-Methoxy-1-methylisoquinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8 - Methoxy - 1 - Methylisoquinoline

There total 2 articles about 8 - Methoxy - 1 - Methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methylmagnesium bromide (75-16-1) + 1-Chloro-8-methoxyisoquinoline (129959-06-4) → 8-methoxy-1-methylisoquinoline (1231948-70-1)

Guidance literature:

iron(III)-acetylacetonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; at 20 ℃; for 2h;

Reference yield: 14.0%

vinyl acetate (108-05-4,9003-20-7) + (E)-1-(2-methoxyphenyl) ethanone O-acetyl oxime (1257846-22-2) → 8-methoxy-1-methylisoquinoline (1231948-70-1)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; at 60 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2018.05.063

upstream raw materials:

methylmagnesium bromide

1-Chloro-8-methoxyisoquinoline

vinyl acetate

(E)-1-(2-methoxyphenyl) ethanone O-acetyl oxime