5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Base Information

• Chemical Name: 5H-pyrrolo[3,4-b]pyridin-7(6H)-one
• CAS No.: 1211584-54-1
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.137
• Hs Code.: 2933990090
• Mol file: 1211584-54-1.mol

Synonyms:5H-pyrrolo[3,4-b]pyridin-7(6H)-one;7H-Pyrrolo[3,4-b]pyridin-7-one, 5,6-dihydro-

Chemical Property of 5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Chemical Property:

• Boiling Point: 441.7±34.0 °C(Predicted)
• PKA: 12.51±0.20(Predicted)
• PSA: 45.48000
• Density: 1.286±0.06 g/cm3(Predicted)
• LogP: 0.33540
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

5H-Pyrrolo[3,4-b]pyridin-7(6H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-pyrrolo[3,4-b]pyridin-7(6H)-one

There total 5 articles about 5H-pyrrolo[3,4-b]pyridin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 3-(azidomethyl)picolinate → 5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one (1211584-54-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 23 ℃; for 2h; under 760.051 Torr;

Reference yield:

3-methyl-pyridine-2-carboxylic acid methyl ester (59718-84-2) → 5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one (1211584-54-1)

Guidance literature:

3-methyl-pyridine-2-carboxylic acid methyl ester; With N-Bromosuccinimide; 1,1'-azobis(1-cyanocyclohexanenitrile); In tetrachloromethane; Reflux;

With ammonia; In methanol; Reflux;

Reference yield:

ethyl 3-methylpyridine-2-carboxylate (58997-10-7) → 5,6-dihydro-pyrrolo[3,4-b]pyridin-7-one (1211584-54-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / chloroform / 100 °C / Sealed tube

2: sodium azide / water / 1 h / 60 °C

3: hydrogen; palladium on activated charcoal / ethanol / 2 h / 23 °C / 760.05 Torr

With N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); palladium on activated charcoal; hydrogen; In ethanol; chloroform; water;

upstream raw materials:

3-methyl-pyridine-2-carboxylic acid methyl ester

ethyl 3-methylpyridine-2-carboxylate

3-methyl-pyridine-2-carboxylic acid

ethyl 3-(bromomethyl)pyridine-2-carboxylate

Refernces

• 1、 -. "BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY". Page/Page column 125. . Retrieved 2014/05/07.