4-chloro-7-fluoro-2-methylquinazoline

Base Information

• Chemical Name: 4-chloro-7-fluoro-2-methylquinazoline
• CAS No.: 1206694-32-7
• Molecular Formula: C9H6ClFN2
• Molecular Weight: 196.611
• Hs Code.: 2933990090
• Mol file: 1206694-32-7.mol

Synonyms:4-chloro-7-fluoro-2-methylquinazoline

Chemical Property of 4-chloro-7-fluoro-2-methylquinazoline

Chemical Property:

• Boiling Point: 216℃
• Flash Point: 84℃
• PSA: 25.78000
• Density: 1.380
• LogP: 2.73070
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-7-fluoro-2-methylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-7-fluoro-2-methylquinazoline

There total 1 articles about 4-chloro-7-fluoro-2-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-fluoro-2-methylquinazolin-4(3H)-one (194473-03-5) → 4-chloro-7-fluoro-2-methyl-quinazoline (1206694-32-7)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/ol902759k

Reference yield: 68.65%

4-chloro-7-fluoro-2-methyl-quinazoline (1206694-32-7) + 4-[(1S)-1-aminoethyl]-benzoic acid, methyl ester (222714-37-6) → methyl 4-[(1S)-1-[(7-fluoro-2-methylquinazolin-4-yl)amino]ethyl]benzoate

Guidance literature:

With triethylamine; In butan-1-ol; at 120 ℃; for 12h;

Reference yield: 55.54%

4-chloro-7-fluoro-2-methyl-quinazoline (1206694-32-7) + (S)-1-(4-bromophenyl)ethylamine (27298-97-1) → N-[(1S)-1-(4-bromophenyl)ethyl]-7-fluoro-2-methylquinazolin-4-amine

Guidance literature:

With triethylamine; In butan-1-ol; at 120 ℃; for 12h;

upstream raw materials:

7-fluoro-2-methylquinazolin-4(3H)-one

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