194473-03-5

Basic information

• Product Name: 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE
• Synonyms: 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE;7-fluoro-2-methylquinazolin-4-ol;7-Fluoro-2-Methylquinazolin-4(3H)-one;7-Fluoro-2-methyl-1H-quinazolin-4-one
• CAS NO: 194473-03-5
• Molecular Formula: C₉H₇FN₂O
• Molecular Weight: 178.17
• Mol File: 194473-03-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.37
• Refractive Index: 1.649
• CAS DataBase Reference: 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE(194473-03-5)
• EPA Substance Registry System: 7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE(194473-03-5)

Safety Data

• Hazardous Substances Data: 194473-03-5(Hazardous Substances Data)

Usage

General Description

7-FLUORO-2-METHYL-3H-QUINAZOLIN-4-ONE is a chemical compound with the molecular formula C10H7FN2O. It belongs to the quinazolinone class of compounds and is characterized by a fluorine atom and a methyl group attached to the quinazolinone ring structure. It has potential biological activity and has been the subject of research for its potential medicinal applications. The compound's structure and properties make it a promising candidate for further study in the development of pharmaceuticals and other applications in the field of chemistry and medicine.

InChI:InChI=1/C9H7FN2O/c1-5-11-8-4-6(10)2-3-7(8)9(13)12-5/h2-4H,1H3,(H,11,12,13)

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 446-32-2 4-fluoroanthranilic acid 
• 128992-48-3 7-fluoro-2-methyl-4H-benzo[d][1,3]-oxazin-4-one 
• 1201935-93-4 2-amino-4-fluoro-N-methoxybenzamide 
• 75-07-0 acetaldehyde 
• 321-50-6 7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 119023-25-5 4-fluoroanthranilamide 
• 631-61-8 ammonium acetate 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 

Downstream Products

• 1206694-32-7 4-chloro-7-fluoro-2-methyl-quinazoline 

Relevant articles and documents

One-pot synthesis of quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones utilizing N-(2-aminobenzoyl)benzotriazoles

A convenient and efficient method has emerged for the one-pot synthesis of substituted quinazolin-4(3H)ones and nonaromatic alkaloids. 2-Substituted quinazolin-4(3H)-ones, 2,3-disubstituted quinazolin-4(3H)-ones, and 2,3-dihydroquinazolin-4(1H)-ones were obtained at yields of 46% to 95% by a one-pot reaction of N-(2-aminobenzoyl) benzotriazoles with amines and orthoesters or aldehydes under catalyst-free conditions.

Schizocommunin derivative and preparation method and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a schizocommunin derivative and a preparation method and application thereof. The structural formula of the schizocommunin derivative is shown in the description, wherein R1 and R3 are hydrogen or fluorine atoms, R2 is amidogen or substituted amidogen or a five-membered or six-membered heterocycle group, R4 is ahydrogen atom or amidogen or substituted amidogen or a five-membered or six-membered heterocycle group, R5 is a hydrogen atom or amidogen or substituted amidogen or halohydrocarbon or a five-memberedor six-membered heterocycle group, and R6 is a hydrogen atom or an alkyl group; a substituent group is amidogen or a five-membered or six-membered heterocycle group. The schizocommunin derivative hasextremely high binding and stabilizing capacities for telomere DNA which is rich in guanine, has a significant anti-cancer effect, and can be used for preparing anti-cancer drugs which have selectivity. Further experiments show that the schizocommunin derivative has significant inhibition effects on various cancer cell lines and has broad application space in anti-cancer drug preparation.

One-pot synthesis of quinazolinones from anthranilamides and aldehydes via p -toluenesulfonic acid catalyzed cyclocondensation and phenyliodine diacetate mediated oxidative dehydrogenation

A variety of 4(3H)-quinazolinones are synthesized conveniently in one pot from 2-aminobenzamides and aldehydes, via cyclization catalyzed by p-toluenesulfonic acid followed by oxidative dehydrogenation mediated by the hypervalent iodine compound phenyliodine diacetate [PhI(OAc)2, PIDA]. Highlights of the described method include the first synthesis of quinazolinones bearing an N-alkoxy substituent, a new application of phenyliodine diacetate as an efficient dehydrogenative oxidant, and mild reaction conditions. Georg Thieme Verlag Stuttgart, New York.