5-Pyrimidinepropanoic acid, 4-chloro-2,6-dimethyl-, ethyl ester

Base Information

Chemical Name:5-Pyrimidinepropanoic acid, 4-chloro-2,6-dimethyl-, ethyl ester
CAS No.:22814-39-7
Molecular Formula:C11H15ClN2O2
Molecular Weight:242.705
Hs Code.:
Mol file:22814-39-7.mol

Synonyms:5-Pyrimidinepropionic acid, 4-chloro-2,6-dimethyl-, ethyl ester (8CI);

Suppliers and Price of 5-Pyrimidinepropanoic acid, 4-chloro-2,6-dimethyl-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 5-Pyrimidinepropanoic acid, 4-chloro-2,6-dimethyl-, ethyl ester

Chemical Property:

PSA：52.08000
LogP:2.24250

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 5-Pyrimidinepropanoic acid, 4-chloro-2,6-dimethyl-, ethyl ester

There total 3 articles about 5-Pyrimidinepropanoic acid, 4-chloro-2,6-dimethyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 22814-29-5
ethyl 3-(2,6-dimethyl-4-oxo-3H-pyrimidin-5-yl)propionate

: 22814-39-7
ethyl 3-(4-chloro-2,6-dimethylpyrimidin-5-yl)propionate

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; for 2h; Heating;
DOI:10.1021/jm00030a013

Reference yield:

: 1501-06-0
diethyl 2-acetylglutarate

: 22814-39-7
ethyl 3-(4-chloro-2,6-dimethylpyrimidin-5-yl)propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / EtONa / ethanol / 22 h / Heating

2: 72 percent / POCl₃, N,N-dimethylaniline / 2 h / Heating

With sodium ethanolate; N,N-dimethyl-aniline; trichlorophosphate; In ethanol;
DOI:10.1021/jm00030a013