8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:145733-62-6
Molecular Formula:C16H16BrN3O
Molecular Weight:346.227
Hs Code.:2933990090
DSSTox Substance ID:DTXSID40437316
Wikidata:Q72510982
Mol file:145733-62-6.mol

Synonyms:145733-62-6;8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one;8-[(4-Bromophenyl)methyl]-5,8-dihydro-2,4-dimethylpyrido[2,3-d]pyrimidin-7(6H)-one;8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido-[2,3-d]pyrimidin-7(8H)-one;8-[(4-bromophenyl)methyl]-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7-one;Pyrido[2,3-d]pyrimidin-7(6H)-one, 8-[(4-bromophenyl)methyl]-5,8-dihydro-2,4-dimethyl-;C16H16BrN3O;SCHEMBL7016278;DTXSID40437316;RIGIQZIXVFCURM-UHFFFAOYSA-N;AMY31186;AKOS000277972;A847329;AU-059/43517546;8-(4-bromobenzyl)-2,4-dimethyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one;8-[(4-Bromophenyl)methyl]-2,4-dimethyl-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one

Suppliers and Price of 8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido-[2,3-d]pyrimidin-7(8H)-one 95+%
1g
$ 1092.00

Matrix Scientific
8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido-[2,3-d]pyrimidin-7(8H)-one 95+%
250mg
$ 492.00

Crysdot
8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one 95+%
1g
$ 510.00

American Custom Chemicals Corporation
8-(4-BROMOBENZYL)-2,4-DIMETHYL-5,6-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 95.00%
5MG
$ 501.69

Alichem
8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one
1g
$ 457.60

AK Scientific
8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one
250mg
$ 714.00

Total 11 raw suppliers

Chemical Property of 8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

Chemical Property:

Boiling Point:571.3±50.0 °C(Predicted)
PKA:6.41±0.20(Predicted)
PSA：46.09000
Density:1.458
LogP:3.40030
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:345.04767
Heavy Atom Count:21
Complexity:384

Purity/Quality:

97% ^*data from raw suppliers

8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido-[2,3-d]pyrimidin-7(8H)-one 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2CCC(=O)N(C2=NC(=N1)C)CC3=CC=C(C=C3)Br

Technology Process of 8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one

There total 4 articles about 8-(4-Bromobenzyl)-2,4-dimethyl-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 22814-39-7
ethyl 3-(4-chloro-2,6-dimethylpyrimidin-5-yl)propionate

: 26177-44-6
4-bromobenzylamine hydrochloride

: 145733-62-6
2,4-dimethyl-5,6,8-trihydro-8-[(4-bromophenyl)methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With sodium hydrogencarbonate; In butan-1-ol; for 48h; Heating;
DOI:10.1021/jm00030a013

Reference yield:

: nBuOH

: 22814-39-7
ethyl 3-(4-chloro-2,6-dimethylpyrimidin-5-yl)propionate

: 26177-44-6
4-bromobenzylamine hydrochloride

: 145733-62-6
2,4-dimethyl-5,6,8-trihydro-8-[(4-bromophenyl)methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With sodium hydrogencarbonate;

Reference yield:

: 1501-06-0
diethyl 2-acetylglutarate

: 145733-62-6
2,4-dimethyl-5,6,8-trihydro-8-[(4-bromophenyl)methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / EtONa / ethanol / 22 h / Heating

2: 72 percent / POCl₃, N,N-dimethylaniline / 2 h / Heating

3: 69 percent / NaHCO₃ / butan-1-ol / 48 h / Heating

With sodium ethanolate; sodium hydrogencarbonate; N,N-dimethyl-aniline; trichlorophosphate; In ethanol; butan-1-ol;
DOI:10.1021/jm00030a013