2-CHLORO-3-ETHYNYLQUINOLINE

Base Information

• Chemical Name: 2-CHLORO-3-ETHYNYLQUINOLINE
• CAS No.: 1000782-65-9
• Molecular Formula: C11H6ClN
• Molecular Weight: 187.62
• Mol file: 1000782-65-9.mol

Synonyms:2-CHLORO-3-ETHYNYLQUINOLINE;Quinoline, 2-chloro-3-ethynyl-

Chemical Property of 2-CHLORO-3-ETHYNYLQUINOLINE

Chemical Property:

• PSA: 12.89000
• LogP: 2.86950

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-ethynylquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-3-ETHYNYLQUINOLINE

There total 6 articles about 2-CHLORO-3-ETHYNYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-3-[2-(trimethylsilyl)ethynyl]quinoline → 2-chloro-3-ethynylquinoline (1000782-65-9)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2007.09.075

Reference yield: 83.0%

2-chloro-3-quinoline carboxaldehyde (73568-25-9) + carbon tetrabromide (558-13-4) → 2-chloro-3-ethynylquinoline (1000782-65-9)

Guidance literature:

2-chloro-3-quinoline carboxaldehyde; carbon tetrabromide; With triisopropyl phosphite; In acetonitrile; at 0 ℃; for 0.166667h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1002/adsc.201801334

Reference yield: 75.0%

2-chloro-3-(2,2-dibromovinyl)-quinoline → 2-chloro-3-ethynylquinoline (1000782-65-9)

Guidance literature:

With sodiumsulfide nonahydrate; In dimethyl sulfoxide; at 20 ℃; for 2h; Solvent; Temperature;

DOI:10.1039/c7ob02431b

upstream raw materials:

2-chloro-3-quinoline carboxaldehyde

carbon tetrabromide

Refernces

• 1、 Palimkar, Sanjay S.,More, Vijaykumar S.,Kumar, P. Harish,Srinivasan, Kumar V.. "Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step". . p. 12786 - 12790. Retrieved 2007.
• 2、 Singh, Radhey M.,Nandini, Durgesh,Bharadwaj, Kishor Chandra,Gupta, Tanu,Singh, Raj Pal. "Na2S-mediated synthesis of terminal alkynes from: Gem -dibromoalkenes". supporting information. p. 9979 - 9982. Retrieved 2017/12/26.