3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID 2-ETHYL ESTER

Base Information

• Chemical Name: 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID 2-ETHYL ESTER
• CAS No.: 5408-10-6
• Molecular Formula: C10H12NO4-
• Molecular Weight: 211.218
• Hs Code.: 2933990090
• Mol file: 5408-10-6.mol

Synonyms:5-(ethoxycarbonyl)-2,4-dimethylpyrrole-3-carboxylic acid;3,5-Dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-ethyl ester;3,5-dimethyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester;2-Ethoxycarbonyl-3,5-dimethyl-1H-pyrrole-3-carboxylic acid;2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolecarboxylic acid;2,4-Dimethyl-5-ethoxycarbonyl-3-carbonsaeure-pyrrol;2,4-Dimethyl-3-carboxy-5-ethoxycarbonyl-pyrrol;3,5-Dimethyl-pyrrol-2,4-dicarbonsaeure-2-aethylester;1H-Pyrrole-2,4-dicarboxylic acid,3,5-dimethyl-,2-ethyl ester;5-(Ethoxycarbonyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;

Chemical Property of 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID 2-ETHYL ESTER

Chemical Property:

• Vapor Pressure: 4.91E-07mmHg at 25°C
• Boiling Point: 397.6°Cat760mmHg
• Flash Point: 194.3°C
• PSA: 79.39000
• Density: 1.262g/cm³
• LogP: 1.50640

Purity/Quality:

98% ^*data from raw suppliers

5-(Ethoxycarbonyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID 2-ETHYL ESTER

There total 7 articles about 3,5-DIMETHYL-1H-PYRROLE-2,4-DICARBOXYLIC ACID 2-ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester (312510-33-1) → 2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolecarboxylic acid (5408-10-6)

Guidance literature:

With ethanol; nickel; at 50 ℃; under 73550.8 Torr; Hydrogenation;

DOI:10.1039/jr9520004176

Reference yield:

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate (2436-79-5) → 2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolecarboxylic acid (5408-10-6)

Guidance literature:

With sulfuric acid; at 40 ℃;

Reference yield:

2-acetoacetic acid (541-50-4) + ethyl 2-hydroxyimino-3-oxobutanoate (5408-04-8) → 2,4-dimethyl-5-ethoxycarbonyl-3-pyrrolecarboxylic acid (5408-10-6)

Guidance literature:

With sodium hydroxide; sodium dithionite; at 40 ℃;

upstream raw materials:

diethyl 2,4-dimethylpyrrole-3,5-dicarboxylate

3,5-dimethyl-pyrrole-2,4-dicarboxylic acid 4-tert-butyl ester 2-ethyl ester

3,5-dimethyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-benzyl ester

2-acetoacetic acid

Downstream raw materials:

3,5-dimethyl-pyrrole-2-carboxylic acid hydrazide

ethyl 4-iodo-3,5-dimethyl-1H-pyrrole-2-carboxylate

NSC 15758

ethyl 3,5-dimethyl-4-formyl-1H-pyrrole-2-carboxylate