5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine
• CAS No.: 219762-28-4
• Molecular Formula: C₇H₆BrN₃
• Molecular Weight: 212.049
• Hs Code.: 2933990090
• Mol file: 219762-28-4.mol

Synonyms:5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine;5-broMo-2-Methyl-3H-iMidazo[4

Chemical Property of 5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 415.918°C at 760 mmHg
• PKA: 7.69±0.40(Predicted)
• Flash Point: 205.34°C
• PSA: 41.57000
• Density: 1.756g/cm³
• LogP: 2.02880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-2-methyl-3H-imidazo[4,5-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine

There total 10 articles about 5-bromo-2-methyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Trimethyl orthoacetate (1445-45-0) + 2,3-Diamino-6-bromopyridine (129012-04-0) → 5-bromo-2-methyl-1H-imidazo[4,5-b]pyridine (219762-28-4)

Guidance literature:

With acetic acid; In methanol; at 100 ℃; for 16h;

Reference yield:

active charcoal + 2,3-Diamino-6-bromopyridine (129012-04-0) + Triethyl orthoacetate (78-39-7) → 5-bromo-2-methyl-1H-imidazo[4,5-b]pyridine (219762-28-4)

Guidance literature:

With potassium carbonate; In dichloromethane; acetic acid;

Reference yield:

2,3-Diamino-6-bromopyridine (129012-04-0) + Triethyl orthoacetate (78-39-7) → 5-bromo-2-methyl-1H-imidazo[4,5-b]pyridine (219762-28-4)

Guidance literature:

In acetic acid; for 29h; Heating / reflux;

upstream raw materials:

2,3-Diamino-6-bromopyridine

Triethyl orthoacetate

5-chloro-2-methyl-1⁽³⁾H-imidazo[4,5-b]pyridine

2-(acetamido)-6-bromo-3-nitropyridine

Downstream raw materials:

2-methyl-1H-imidazo[4,5-b]pyridine-5-carbonitrile

5-bromo-3-(2-chloro-4-phenylbenzyl)-2-methyl-3H-imidazo[4,5-b]pyridine

5-bromo-1-(2-chloro-4-phenylbenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine

5-bromo-1-(2-bromo-4-chlorobenzyl)-2-methyl-1H-imidazo[4,5-b]pyridine