tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS No.: 1160246-91-2
• Molecular Formula: C13H24N2O3
• Molecular Weight: 256
• Hs Code.: 2934999090
• Mol file: 1160246-91-2.mol

Synonyms:tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-aMino-, 1,1-diMethylethyl ester;8-Boc-3-aMino-1-oxa-8-azaspiro[4.5]decane;3-Amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Chemical Property of tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property:

• Boiling Point: 364.4±42.0 °C(Predicted)
• PKA: 9.77±0.20(Predicted)
• PSA: 64.79000
• Density: 1.12
• LogP: 2.14190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

8-Boc-3-amino-1-oxa-8-azaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

There total 5 articles about tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (954236-44-3) → tert-butyl (3R)-3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1160246-91-2)

Guidance literature:

With potassium phosphate; pyridoxal 5'-phosphate; isopropylamine hydrochloride; potassium hydroxide; magnesium chloride; In water; dimethyl sulfoxide; at 30 - 40 ℃; for 29h; pH=8; Inert atmosphere; Enzymatic reaction;

Reference yield:

tert-butyl 3-azido-1-oxa-8-azaspiro[4.5]decane-8-carboxylate → tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1160246-91-2)

Guidance literature:

With water; triphenylphosphine; at 20 ℃; for 16h;

DOI:10.1021/acs.oprd.1c00075

Reference yield:

tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (898157-46-5) → tert-butyl 3-amino-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1160246-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 24 h / 50 °C

2: triphenylphosphine; water / 16 h / 20 °C

With sodium azide; water; triphenylphosphine; In dimethyl sulfoxide;

DOI:10.1021/acs.oprd.1c00075

upstream raw materials:

tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine

tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

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