1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester

Base Information

• Chemical Name: 1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester
• CAS No.: 898157-46-5
• Molecular Formula: C13H22BrNO3
• Molecular Weight: 320.227
• Mol file: 898157-46-5.mol

Synonyms:1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester;tert-butyl3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property of 1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester

Chemical Property:

• Vapor Pressure: 4.98E-06mmHg at 25°C
• Boiling Point: 381.7°C at 760 mmHg
• Flash Point: 184.6°C
• PSA: 38.77000
• Density: 1.35g/cm³
• LogP: 2.87780

Purity/Quality:

97% ^*data from raw suppliers

1-OXA-8-AZASPIRO-[4.5]-DECANE-8-CARBOXYLIC ACID-3-BROMO-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester

There total 5 articles about 1-Oxa-8-azaspiro[4,5]decane-8-carboxylic acid,3-bromo-,1,1-dimethylethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

tert-butyl 4-(2,3-dibromopropyl)-4-hydroxypiperidine-1-carboxylate → tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (898157-46-5)

Guidance literature:

With potassium carbonate; In methanol; at 10 - 15 ℃; for 16h;

Reference yield: 57.0%

1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine (203662-51-5) → tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (898157-46-5)

Guidance literature:

1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine; With bromine; In dichloromethane; at 0 - 20 ℃; for 1h;

With potassium carbonate; In methanol; at 10 ℃; for 6h;

DOI:10.1021/acs.oprd.1c00075

Reference yield: 42.0%

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate (240401-09-6) → tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (898157-46-5)

Guidance literature:

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate; With carbon tetrabromide; In dichloromethane; for 0.166667h;

With triphenylphosphine; In dichloromethane; at -5 - 20 ℃;

upstream raw materials:

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[ 4.5]decane-8-carboxylate

tert-butyl 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

tert-butyl 3-[3-(trifluoromethoxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl (3RS)-3-[3-(benzyloxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

C₁₅H₁₈F₃NO₂