4-BROMO-7-METHOXY-1H-INDOLE

Base Information

• Chemical Name: 4-BROMO-7-METHOXY-1H-INDOLE
• CAS No.: 436091-59-7
• Molecular Formula: C9H8BrNO
• Molecular Weight: 226.073
• Hs Code.: 2933990090
• Mol file: 436091-59-7.mol

Synonyms:4-bromo-7-methoxy-1H-indole

Chemical Property of 4-BROMO-7-METHOXY-1H-INDOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 356.49°C at 760 mmHg
• PKA: 15.56±0.30(Predicted)
• Flash Point: 169.4°C
• PSA: 25.02000
• Density: 1.591g/cm³
• LogP: 2.93900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-7-methoxy-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-BROMO-7-METHOXY-1H-INDOLE

There total 8 articles about 4-BROMO-7-METHOXY-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

C13H15BrN2O3 → 4-bromo-7-methoxy-1H-indole (436091-59-7)

Guidance literature:

C₁₃H₁₅BrN₂O₃; With acetic acid; zinc; for 0.5h; Reflux;

With sodium carbonate; In water; at 20 ℃;

Reference yield: 44.0%

1-bromo-4-methoxy-2-methyl-3-nitro-benzene (85598-13-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-bromo-7-methoxy-1H-indole (436091-59-7)

Guidance literature:

1-bromo-4-methoxy-2-methyl-3-nitro-benzene; N,N-dimethyl-formamide dimethyl acetal; With pyrrolidine; In N,N-dimethyl-formamide; at 90 ℃; for 18h;

With iron; acetic acid; for 1h; Reflux;

With sodium carbonate; In water;

Reference yield: 11.0%

4-bromo-1-methoxy-2-nitrobenzene (33696-00-3) + vinyl magnesium bromide (1826-67-1) → 4-bromo-7-methoxy-1H-indole (436091-59-7)

Guidance literature:

4-bromo-1-methoxy-2-nitrobenzene; vinyl magnesium bromide; In tetrahydrofuran; at -40 ℃; for 4h;

With ammonium chloride; In tetrahydrofuran;

upstream raw materials:

3-methyl-2-nitrophenol

4-bromo-3-methyl-2-nitro-phenol

1-bromo-4-methoxy-2-methyl-3-nitro-benzene

3-methyl-phenol

Downstream raw materials:

4-bromo-7-methoxy-1-(phenylsulfonyl)-1H-indole

1-bromo-3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-butan-2-one

1-hydroxy-3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-butan-2-one

methanesulfonic acid 3-[7-methoxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-2-oxo-butyl ester