(S)-tert-butyl 3-((S)-1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 3-((S)-1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylate
• CAS No.: 1251570-88-3
• Molecular Formula: C14H27NO3
• Molecular Weight: 257
• Hs Code.: 2933990090
• Mol file: 1251570-88-3.mol

Synonyms:(S)-tert-butyl 3-((S)-1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylate;(S)-tert-butyl 3-((S)-1-hydroxy-3-Methylbutyl)pyrrolidine-1-carb

Chemical Property of (S)-tert-butyl 3-((S)-1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylate

Chemical Property:

• PSA: 49.77000
• LogP: 2.58830
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl 3-((S)-1-hydroxy-3-methylbutyl)-pyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 3-((S)-1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylate

There total 19 articles about (S)-tert-butyl 3-((S)-1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl (S)-3-((S)-1-(benzyloxy)-3-methylbutyl)pyrrolidine-1-carboxylate → tert-butyl (3S)-3-[(1S)-1-hydroxy-3-methyl-butyl]pyrrolidine-1-carboxylate (1251570-88-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h; under 760.051 Torr;

DOI:10.1016/j.tetlet.2017.07.069

Reference yield: 45.0%

tert-butyl (3S)-3-(3-methylbutanoyl)pyrrolidine-1-carboxylate (1251570-77-0) → tert-butyl (3S)-3-[(1S)-1-hydroxy-3-methyl-butyl]pyrrolidine-1-carboxylate (1251570-88-3)

Guidance literature:

tert-butyl (3S)-3-(3-methylbutanoyl)pyrrolidine-1-carboxylate; With methanol; sodium tetrahydroborate; at 20 - 30 ℃; for 3.5h;

In n-heptane; isopropyl alcohol;

DOI:10.1021/ml400049p

Reference yield:

2-methylpropylmagnesium chloride (5674-02-2) + (S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester (191348-04-6) → (3S)-3-(1-hydroxy-3-methylbutyl)pyrrolidine-1-carboxylic acid tert-butyl ester (1251570-86-1) + tert-butyl (3S)-3-[(1S)-1-hydroxy-3-methyl-butyl]pyrrolidine-1-carboxylate (1251570-88-3)

Guidance literature:

2-methylpropylmagnesium chloride; (S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃;

upstream raw materials:

tert-butyl (3S)-3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

2-methylpropylmagnesium chloride

(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester

methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate