(S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate
CAS No.:1251570-77-0
Molecular Formula:C14H25NO3
Molecular Weight:255
Hs Code.:2933990090
Mol file:1251570-77-0.mol

Synonyms:(S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate;(S)-1-Boc-3-(3-Methylbutanoyl)pyrrolidine

Suppliers and Price of (S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl3-(3-methylbutanoyl)pyrrolidine-1-carboxylate 95+%
1g
$ 931.00

Chemenu
(S)-tert-Butyl3-(3-methylbutanoyl)pyrrolidine-1-carboxylate 95%
1g
$ 878.00

American Custom Chemicals Corporation
(S)-1-BOC-3-(3-METHYLBUTANOYL)PYRROLIDINE 95.00%
1G
$ 1371.30

American Custom Chemicals Corporation
(S)-1-BOC-3-(3-METHYLBUTANOYL)PYRROLIDINE 95.00%
5MG
$ 496.61

Total 12 raw suppliers

Chemical Property of (S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：46.61000
LogP:2.79650
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl3-(3-methylbutanoyl)pyrrolidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

There total 6 articles about (S)-tert-butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

: 1204677-53-1
tert-butyl (3S)-3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

: 926-62-5
isobutylmagnesium bromide

: 1251570-77-0
tert-butyl (3S)-3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl (3S)-3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate; isobutylmagnesium bromide; In tetrahydrofuran; at -7 - 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield: 94.0%

: 1204677-53-1
tert-butyl (3S)-3-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

: 5674-02-2
2-methylpropylmagnesium chloride

: 1251570-77-0
tert-butyl (3S)-3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 22 ℃; for 16.5h; Inert atmosphere;
DOI:10.1021/ml400049p

Reference yield:

: 122684-33-7
methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate

: 1251570-77-0
tert-butyl (3S)-3-(3-methylbutanoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / aq. phosphate buffer / 20.5 h / 20 °C / pH 7.5

2.1: lithium hydroxide; water / tetrahydrofuran / 22 °C

3.1: dichloromethane / 1 h / 22 °C / Inert atmosphere

4.1: dichloromethane / 72 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: tetrahydrofuran / 16.5 h / 22 °C / Inert atmosphere

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; aq. phosphate buffer; dichloromethane;
DOI:10.1021/ml400049p