5-AMINOTHIAZOLE HCL

Base Information

• Chemical Name: 5-AMINOTHIAZOLE HCL
• CAS No.: 942631-51-8
• Molecular Formula: C3H4N2S.ClH
• Molecular Weight: 136.6
• Hs Code.: 2934100090
• Mol file: 942631-51-8.mol

Synonyms:5-AMINOTHIAZOLE HCL;5-Aminothiazole hydrochloride;Thiazol-5-ylamine hydrochloride;5-Thiazolamine HCl;thiazol-5-aMine hydrochloride;Thiazol-5-ylaMine

Chemical Property of 5-AMINOTHIAZOLE HCL

Chemical Property:

• PSA: 67.15000
• LogP: 2.10850
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

5-ThiazolamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINOTHIAZOLE HCL

There total 1 articles about 5-AMINOTHIAZOLE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl thiazol-5-ylcarbamate (942631-50-7) → thiazol-5-amine hydrochloride (942631-51-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2018.12.029

Reference yield: 70.0%

thiazol-5-amine hydrochloride (942631-51-8) + acetic anhydride (108-24-7) → N-(thiazol-5-yl)acetamide (408507-23-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2018.12.029

Reference yield:

thiazol-5-amine hydrochloride (942631-51-8) + 4-(2-bromo-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride (1450923-16-6) → 4-(2-bromo-4-(trifluoromethyl)phenyl)-N-(thiazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (1450923-54-2)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

upstream raw materials:

tert-butyl thiazol-5-ylcarbamate

Downstream raw materials:

4-(2-bromo-4-(trifluoromethyl)phenyl)-N-(thiazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

N-(thiazol-5-yl)acetamide

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