408507-23-3Relevant articles and documents
Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors
Geneste, Hervé,Drescher, Karla,Jakob, Clarissa,Laplanche, Lo?c,Ochse, Michael,Torrent, Maricel
, p. 406 - 412 (2019/01/04)
Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribu
Azole series. I. Reaction of 2-(acylamino)thioacetamides, leading to 5-aminothiazoles and to thiazolo[5,4-d]pyrimidines.
Sekiya,Osaki
, p. 1319 - 1325 (2007/10/07)
-