408507-23-3Relevant articles and documents
Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors
Geneste, Hervé,Drescher, Karla,Jakob, Clarissa,Laplanche, Lo?c,Ochse, Michael,Torrent, Maricel
, p. 406 - 412 (2019/01/04)
Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribu
NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
-
Page/Page column 55, (2014/04/03)
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. where in formula I the variables X, Y, Q1, Q2 have the following meanings: X is C-R