2,4-di-chloropyrimidine 5-carboxylic acid amide

Base Information

• Chemical Name: 2,4-di-chloropyrimidine 5-carboxylic acid amide
• CAS No.: 1240390-28-6
• Molecular Formula: C50H3Cl2N3O
• Molecular Weight: 192.004
• Hs Code.: 2933599090
• Mol file: 1240390-28-6.mol

Synonyms:2,4-Dichloropyrimidine-5-carboxamide;

Chemical Property of 2,4-di-chloropyrimidine 5-carboxylic acid amide

Chemical Property:

• Boiling Point: 364℃
• PKA: 12.74±0.50(Predicted)
• Flash Point: 174℃
• PSA: 68.87000
• Density: 1.620
• LogP: 1.58260
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,4-Dichloropyrimidine-5-carboxamide ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-di-chloropyrimidine 5-carboxylic acid amide

There total 2 articles about 2,4-di-chloropyrimidine 5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,4-dichloropyrimidine-5-carbonyl chloride (2972-52-3) → 2,4-dichloro-pyrimidine-5-carboxylic acid amide (1240390-28-6)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

2,4-dihydroxypyrimidine-5-carboxylic acid (23945-44-0) → 2,4-dichloro-pyrimidine-5-carboxylic acid amide (1240390-28-6)

Guidance literature:

2,4-dihydroxypyrimidine-5-carboxylic acid; With trichlorophosphate; at 100 ℃; for 4h;

With ammonium hydroxide; In water;

Reference yield: 99.0%

2,4-dichloro-pyrimidine-5-carboxylic acid amide (1240390-28-6) + 1-(3-aminophenyl)-3-methylimidazolidin-2-one (517918-82-0) + tert-butyl (S)-piperidin-3-yl-carbamate (216854-23-8,172603-05-3) → C20H26N8O2*(x)ClH

Guidance literature:

2,4-dichloro-pyrimidine-5-carboxylic acid amide; 1-(3-aminophenyl)-3-methylimidazolidin-2-one; With triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 50 ℃; for 2h;

tert-butyl (S)-piperidin-3-yl-carbamate; With triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 50 ℃; for 1.5h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃;

upstream raw materials:

2,4-dichloropyrimidine-5-carbonyl chloride

2,4-dihydroxypyrimidine-5-carboxylic acid

Downstream raw materials:

2-chloro-4-[(4-methylphenyl)amino]-5-pyrimidinecarboxamide

2-chloro-4-(1-phenylethylamino)pyrimidine-5-carboxamide

5-aminocarbonyl-2-chloro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)-4-pyrimidineamine hydrochloride

2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

Refernces

• 1、 -. "JNK inhibitor as well as pharmaceutical composition and application thereof". Paragraph 0406-0407; 0410-0411; 0428-0429; 0432-0433. . Retrieved 2021/03/31.
• 2、 -. "SYNTHESIS OF CERDULATINIB". Paragraph 0101-0103. . Retrieved 2019/11/19.