2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

Base Information

Chemical Name:2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile
CAS No.:1309831-20-6
Molecular Formula:C₂₆H₃₃FN₁₀O
Molecular Weight:520.613
Hs Code.:

2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

Synonyms:2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

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Chemical Property of 2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

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Technology Process of 2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

There total 18 articles about 2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309833-24-6
C₂₆H₃₅FN₁₀O₂

: 1309831-20-6
2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

Guidance literature:: C₂₆H₃₅FN₁₀O₂; With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at -50 - 0 ℃; for 3.5h; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 1309831-20-6
2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid; sulfuric acid / 1.08 h / -20 - -15 °C

2: toluene / 2.5 h / 80 °C / Inert atmosphere

3: trimethylsilylazide / 80 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere

5: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

6: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 80 °C

7: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C / Sealed vial

8: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 3.5 h / -50 - 0 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; trimethylsilylazide; sulfuric acid; nitric acid; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 5: Suzuki Coupling;

Reference yield:

: 346433-97-4
2-bromo-4-fluoro-5-nitrophenylamine

: 1309831-20-6
2-[4-Cyclopropyl-2-fluoro-5-(4-methyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-phenylamino]-4-(1,2,2,6,6-pentamethyl-piperidin-4-ylamino)-pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 2.5 h / 80 °C / Inert atmosphere

2: trimethylsilylazide / 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / -78 - 20 °C / Inert atmosphere

4: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere

5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 80 °C

6: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C / Sealed vial

7: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 3.5 h / -50 - 0 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; trimethylsilylazide; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic anhydride; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 4: Suzuki Coupling;