1-(2-fluoroethyl)-4-Piperidinamine

Base Information

• Chemical Name: 1-(2-fluoroethyl)-4-Piperidinamine
• CAS No.: 947263-70-9
• Molecular Formula: C7H15FN2
• Molecular Weight: 146.208
• Mol file: 947263-70-9.mol

Synonyms:1-(2-Fluoroethyl)piperidin-4-amine;[1-(2-Fluoroethyl)piperidin-4-yl]amine;

Chemical Property of 1-(2-fluoroethyl)-4-Piperidinamine

Chemical Property:

• PSA: 29.26000
• LogP: 1.01720

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(2-Fluoroethyl)piperidin-4-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(2-Fluoroethyl)piperidin-4-amine is used to synthesize glycine transporter inhibitors.

Technology Process of 1-(2-fluoroethyl)-4-Piperidinamine

There total 2 articles about 1-(2-fluoroethyl)-4-Piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (1-(2-fluoroethyl)piperidin-4-yl)carbamate (871014-10-7) → 1-(2-fluoroethyl)piperidin-4-amine (947263-70-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

(piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 1-(2-fluoroethyl)piperidin-4-amine (947263-70-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile / 5 h / Heating

2: TFA / 1 h

With potassium carbonate; trifluoroacetic acid; In acetonitrile;

DOI:10.1021/jm0701627

Reference yield: 68.0%

1-(2-fluoroethyl)piperidin-4-amine (947263-70-9) + 4-Bromobenzoic acid (586-76-5) → 4-bromo-N-(1-(2-fluoroethyl)piperidin-4-yl)benzamide

Guidance literature:

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1021/jm0701627

upstream raw materials:

tert-butyl (1-(2-fluoroethyl)piperidin-4-yl)carbamate

(piperidin-4-yl)carbamic acid tert-butyl ester

Refernces

• 1、 Pham, Tien Q.,Greguric, Ivan,Liu, Xiang,Berghofer, Paula,Ballantyne, Patrice,Chapman, Janette,Mattner, Filomena,Dikic, Branko,Jackson, Timothy,Loc'h, Christian,Katsifis, Andrew. "Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma". . p. 3561 - 3572. Retrieved 2008/02/09.