3-hydroxy-3-(trifluoromethyl)indolin-2-one

Base Information

• Chemical Name: 3-hydroxy-3-(trifluoromethyl)indolin-2-one
• CAS No.: 98294-08-7
• Molecular Formula: C₉H₆F₃NO₂
• Molecular Weight: 217.147
• Mol file: 98294-08-7.mol

Synonyms:3-hydroxy-3-(trifluoromethyl)indolin-2-one;3-hydroxy-3-(trifluoromethyl)-1H-indol-2-one;3-Hydroxy-3-trifluoromethyl-1,3-dihydro-indol-2-one;1,3-dihydro-3-hydroxy-3-(trifluoromethyl)-2H-Indol-2-one;3-hydroxy-3-(trifluoroMethyl)-2,3-dihydro-1H-indol-2-one

Chemical Property of 3-hydroxy-3-(trifluoromethyl)indolin-2-one

Chemical Property:

• PSA: 52.82000
• LogP: 1.47370

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-3-(trifluoromethyl)indolin-2-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxy-3-(trifluoromethyl)indolin-2-one

There total 7 articles about 3-hydroxy-3-(trifluoromethyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) + (trifluoromethyl)trimethylsilane (81290-20-2) → 3-hydroxy-3-trifluoromethylbenzopyrrolidin-2-one (98294-08-7)

Guidance literature:

With potassium fluoride; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1021/jm020546r

Reference yield: 61.44%

methyl 3,3,3-trifluoropyruvate (13089-11-7) + aniline (62-53-3) → 3-hydroxy-3-trifluoromethylbenzopyrrolidin-2-one (98294-08-7)

Guidance literature:

In benzene; at 120 ℃; for 6h;

DOI:10.1007/BF00948085

Reference yield: 58.2%

8-amino quinoline (578-66-5) + methyl 3,3,3-trifluoropyruvate (13089-11-7) → 3-hydroxy-3-trifluoromethylbenzopyrrolidin-2-one (98294-08-7) + 8-amino-5-(α-hydroxy-α-carbethoxytrifluoroethyl)quinoline

Guidance literature:

In chloroform; at 20 ℃;

DOI:10.1007/BF00954027

upstream raw materials:

8-amino quinoline

methyl 3,3,3-trifluoropyruvate

aniline

indole-2,3-dione

Downstream raw materials:

3-hydroxy-3-(trifluoromethyl)indolin-2-one

3-hydroxy-3-(trifluoromethyl)indolin-2-one

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