1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE HYDROCHLORIDE
• CAS No.: 1075729-10-0
• Molecular Formula: C12H13N3.ClH
• Molecular Weight: 235.716
• Hs Code.: 2933990090
• Mol file: 1075729-10-0.mol

Synonyms:4,5,6,7-TETRAHYDRO-1-PHENYL-1H-PYRAZOLO[4,3-C]PYRIDINE HCL;1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE HYDROCHLORIDE;1-Phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine dihydrochloride

Chemical Property of 1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 29.85000
• LogP: 2.64880

Purity/Quality:

98%min ^*data from raw suppliers

4,5,6,7-Tetrahydro-1-phenyl-1H-pyrazolo[4,3-c]pyridineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE HYDROCHLORIDE

There total 2 articles about 1-PHENYL-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (1075729-08-6) → 1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride (1075729-10-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 40 ℃; for 1.5h;

Reference yield:

3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (1202645-17-7) → 1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride (1075729-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 8 h / 85 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 6 h / 0 - 20 °C

With hydrogenchloride; In 1,4-dioxane; ethanol;

Reference yield: 53.0%

1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride (1075729-10-0) + 2,6-difluorobenzoylchloride (18063-02-0) → 2,6-Difluorophenyl(1-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-methanone (1075728-26-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

tert-butyl 1-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

2,6-Difluorophenyl(1-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)-methanone

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