18063-02-0

Basic information

• Product Name: 2,6-Difluorobenzoyl chloride
• Synonyms: LABOTEST-BB LTBB000722;FUROIC ACID;FAC;2,6-DIFLUOROBENZOYL CHLORIDE;2,6-DIFLUOROBENZENE-1-CARBONYL CHLORIDE;2-CARBOXYFURAN;ALPHA-FUROIC ACID;AKOS BBS-00003916
• CAS NO: 18063-02-0
• Molecular Formula: C₇H₃ClF₂O
• Molecular Weight: 176.55
• EINECS: 241-971-2
• Product Categories: Miscellaneous;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 18063-02-0.mol

Chemical Properties

• Melting Point: 128-132 °C(lit.)
• Boiling Point: 72-77 °C13 mm Hg(lit.)
• Flash Point: 121 °F
• Appearance: clear colourless to light yellow liquid
• Density: 1.404 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.14mmHg at 25°C
• Refractive Index: n20/D 1.501(lit.)
• Storage Temp.: 2-8°C
• Water Solubility: REACTS
• Sensitive: Moisture Sensitive
• BRN: 639438
• CAS DataBase Reference: 2,6-Difluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Difluorobenzoyl chloride(18063-02-0)
• EPA Substance Registry System: 2,6-Difluorobenzoyl chloride(18063-02-0)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38-34-10
• Safety Statements: 26-36/37/39-45-28A-16
• RIDADR: UN 2920 8/PG 2
• WGK Germany: 3
• RTECS: LV1763000
• F: 21
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 18063-02-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluorobenzoyl chloride is used as a chemical intermediate for the preparation of a series of novel 2-aryl substituted 4H-3,1-benzoxazin-4-ones, which are important compounds with potential applications in the development of new drugs and pharmaceuticals.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,6-Difluorobenzoyl chloride is utilized for the regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridine, a class of compounds with potential applications in various chemical and pharmaceutical processes.
Used in Friedel-Crafts Acylation:
2,6-Difluorobenzoyl chloride is employed as a reagent in the Friedel-Crafts acylation reaction of various aromatic compounds, such as toluene, anisol, thioanisol, 4-phenoxyacetophenone, and N,N-diacetyl-4-phenoxyaniline. This reaction is a crucial method for the synthesis of various organic compounds and contributes to the development of new materials and chemicals.
Used in Perfumery and Flavoring Industry:
2,6-Difluorobenzoyl chloride is used as a furoates compound in the perfume and flavoring industry, where it contributes to the creation of unique and distinct scents and flavors for various products.
Used in Textile Processing:
In the textile industry, 2,6-Difluorobenzoyl chloride is used for its preservative and bactericide properties, helping to enhance the durability and quality of textiles by protecting them from microbial degradation and other forms of damage.
Used in Fumigation:
As a fumigant, 2,6-Difluorobenzoyl chloride is employed in the agricultural and pest control sectors to protect crops and stored products from infestations by insects and other pests, ensuring the preservation of food and other commodities.

InChI:InChI=1/C6H8O2/c1-2-3-7-4-6-5-8-6/h1,6H,3-5H2

Upstream product

• 385-00-2 2,6-difluorobenzoic acid 
• 372-18-9 1,3-Difluorobenzene 
• 18063-03-1 2,6-difluorobenzamide 

Downstream Products

• 13671-00-6 methyl 2,6-difluorobenzoate 
• 19064-14-3 2,6-Difluorobenzoic acid,ethyl ester 
• 18063-03-1 2,6-difluorobenzamide 
• 148931-18-4 S-allyl N-(2,6-difluorobenzoyl)monothiocarbamate 
• 66648-38-2 2,6-difluoro-hippuric acid 
• 119448-98-5 N-(Bis-methylsulfanyl-methylene)-2,6-difluoro-benzamide 
• 60731-73-9 2,6-difluorobenzoyl isocyanate 
• 136741-45-2 (5-Chloro-2-hydroxy-4-methoxy-phenyl)-(2,6-difluoro-phenyl)-methanone 
• 129355-74-4 [1-(2,6-Difluoro-benzoyl)-5,5-dimethyl-3-oxo-piperazin-2-yl]-acetic acid ethyl ester 
• 129355-62-0 (S)-2-(2,6-Difluoro-benzoylamino)-succinic acid diethyl ester 
• 96348-37-7 5-(2,6-Difluoro-benzoyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid methyl ester 
• 86750-61-0 2,6-Difluoro-N-[1-(toluene-4-sulfonyl)-cyclopropyl]-benzamide 
• 129355-67-5 [1-(2,6-Difluoro-benzoyl)-3-oxo-piperazin-2-yl]-acetic acid ethyl ester 
• 35367-38-5 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea 

Relevant articles and documents

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