Tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate
CAS No.:203519-37-3
Molecular Formula:C14H21ClN4O2
Molecular Weight:312.799
Hs Code.:2933990090
DSSTox Substance ID:DTXSID50595673
Wikidata:Q82490738
Mol file:203519-37-3.mol

Synonyms:203519-37-3;tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate;tert-butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate;TERT-BUTYL 4-(6-CHLORO-2-METHYL-4-PYRIMIDINYL)-TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;SCHEMBL1280129;DTXSID50595673;IHNJQIINOHRIQE-UHFFFAOYSA-N;MFCD09972246;AKOS005073558;MB-0710;MB08343;DA-18908;G76647;J-524646;2-methyl-4-chloro-6-[1-(tert-butoxycarbonyl]piperazin-4-yl)pyrimidine;1-Piperazinecarboxylic acid, 4-(6-chloro-2-methyl-4-pyrimidinyl)-, 1,1-dimethylethyl ester;4-(6-Chloro-2-methyl-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester;4-(6-Chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester;ERT-BUTYL 4-(6-CHLORO-2-METHYL-4-PYRIMIDINYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE;tert-butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)tetrahydro-1(2H)pyrazinecarboxylate

Suppliers and Price of Tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)-tetrahydro-1(2H)-pyrazinecarboxylate >95%
1g
$ 234.00

Matrix Scientific
tert-Butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)-tetrahydro-1(2H)-pyrazinecarboxylate >95%
500mg
$ 172.00

Matrix Scientific
tert-Butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)-tetrahydro-1(2H)-pyrazinecarboxylate >95%
5g
$ 674.00

Crysdot
tert-Butyl4-(6-chloro-2-methyl-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate 95+%
5g
$ 493.00

Chemenu
tert-Butyl4-(6-chloro-2-methyl-4-pyrimidinyl)-tetrahydro-1(2H)-pyrazinecarboxylate 95%
5g
$ 466.00

American Custom Chemicals Corporation
TERT-BUTYL 4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)PIPERAZINE-1-CARBOXYLATE 95.00%
1G
$ 722.80

American Custom Chemicals Corporation
TERT-BUTYL 4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)PIPERAZINE-1-CARBOXYLATE 95.00%
10G
$ 1585.35

American Custom Chemicals Corporation
TERT-BUTYL 4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)PIPERAZINE-1-CARBOXYLATE 95.00%
5G
$ 1115.96

AK Scientific
tert-Butyl4-(6-chloro-2-methyl-4-pyrimidinyl)tetrahydro-1(2H)-pyrazinecarboxylate
5g
$ 959.00

Total 14 raw suppliers

Chemical Property of Tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Chemical Property:

Vapor Pressure:8.42E-08mmHg at 25°C
Melting Point:117～119℃
Boiling Point:435.9°C at 760 mmHg
Flash Point:217.4°C
PSA：58.56000
Density:1.228g/cm³
LogP:2.49840
Storage Temp.:2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:312.1353036
Heavy Atom Count:21
Complexity:367

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl 4-(6-chloro-2-methyl-4-pyrimidinyl)-tetrahydro-1(2H)-pyrazinecarboxylate >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC(=CC(=N1)Cl)N2CCN(CC2)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

There total 2 articles about Tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 203519-37-3
tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 3934-20-1
2,6-Dichloropyrimidine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 203519-37-3
tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

Guidance literature:: With triethylamine; In ethanol; dichloromethane;

Reference yield: 42.0%

: 1003-61-8
2-aminothiazole-5-carbaldehyde

: 203519-37-3
tert-butyl 4-(6-chloro-2-methylpyrimidin-4-yl)piperazine-1-carboxylate

: 936845-85-1
4-[6-(5-formyl-thiazol-2-ylamino)-2-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 7h; Heating / reflux;