1003-61-8Relevant articles and documents
Thiazole-diamides as potent γ-secretase inhibitors
Chen, Yuhpyng L.,Cherry, Kevin,Corman, Michael L.,Ebbinghaus, Charles F.,Gamlath, Chandra B.,Liston, Dane,Martin, Barbara-Anne,Oborski, Christine E.,Sahagan, Barbara G.
, p. 5518 - 5522 (2008/03/14)
The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors. Several representative compounds showed IC50 values of 3H]-2a, are d
SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
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, (2008/06/13)
The use of a compound of formula (I) 1 or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6 alkyl,; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2 ,R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed
Process for preparing 2-amino-5-formylthiazole and its hydrobromide salt
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, (2008/06/13)
Process for the preparation of 5-formyl-2-aminothiazole hydrobromide and 2-amino-5-formylthiazole which comprises reacting bromomalonaldehyde and thiourea in the substantial absence of acid or base to form the 5-formyl-2-aminothiazole hydrobromide, and then treating the same with base to form the aminothiazole.