METHYL 4-CHLORO-3-HYDROXY-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 4-CHLORO-3-HYDROXY-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE
• CAS No.: 104386-68-7
• Molecular Formula: C7H7ClO3S2
• Molecular Weight: 238.7117
• Hs Code.: 2934999090
• Mol file: 104386-68-7.mol

Synonyms:Methyl 4-chloro-3-hydroxy-5-(methylthio)thiophene-2-carboxylate;METHYL 4-CHLORO-3-HYDROXY-5-(METHYLSULFANYL)THIOPHENE-2-CARBOXYLATE;methyl 4-chloro-3-hydroxy-5-methylmercaptothiophene-2-carboxylate;

Chemical Property of METHYL 4-CHLORO-3-HYDROXY-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 317.912°C at 760 mmHg
• Flash Point: 146.068°C
• PSA: 100.07000
• Density: 1.543g/cm³
• LogP: 2.61560
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 4-chloro-3-hydroxy-5-(methylthio)-thiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of METHYL 4-CHLORO-3-HYDROXY-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE

There total 3 articles about METHYL 4-CHLORO-3-HYDROXY-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 4-chloro-3-hydroxy-5-mercaptothiophene-2-carboxylate (104340-93-4) + methyl iodide (74-88-4) → methyl 4-chloro-3-hydroxy-5-methylmercaptothiophene-2-carboxylate (104386-68-7)

Guidance literature:

With sodium methylate; In methanol; for 3h; Heating;

Reference yield:

2,4-dichloro-2-methoxycarbonyl-3-oxo-2,3-dihydrothiophene (65449-58-3) → methyl 4-chloro-3-hydroxy-5-methylmercaptothiophene-2-carboxylate (104386-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / conc. H₂SO₄ / acetic acid / 24 h / Ambient temperature

2: 84 percent / 1N aq.NaOH / 3 h / Ambient temperature

3: 87 percent / MeONa / methanol / 3 h / Heating

With sodium hydroxide; sulfuric acid; sodium methylate; In methanol; acetic acid;

Reference yield:

5-Acetylsulfanyl-4-chloro-3-hydroxy-thiophene-2-carboxylic acid methyl ester (104340-88-7) → methyl 4-chloro-3-hydroxy-5-methylmercaptothiophene-2-carboxylate (104386-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 1N aq.NaOH / 3 h / Ambient temperature

2: 87 percent / MeONa / methanol / 3 h / Heating

With sodium hydroxide; sodium methylate; In methanol;

upstream raw materials:

methyl 4-chloro-3-hydroxy-5-mercaptothiophene-2-carboxylate

methyl iodide

2,4-dichloro-2-methoxycarbonyl-3-oxo-2,3-dihydrothiophene

5-Acetylsulfanyl-4-chloro-3-hydroxy-thiophene-2-carboxylic acid methyl ester

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