3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

Base Information

Chemical Name:3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
CAS No.:886047-13-8
Molecular Formula:C₁₃H₁₄ClN₃O₂S
Molecular Weight:311.792
Hs Code.:2934999090
European Community (EC) Number:686-975-9
UNII:5YG6JK4ECM
ChEMBL ID:CHEMBL3770346
DSSTox Substance ID:DTXSID10468233
Nikkaji Number:J2.629.210G
Pharos Ligand ID:WTKKZ3JNBVP6
Wikidata:Q27082550
Mol file:886047-13-8.mol

Synonyms:3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide;LY2033298

Suppliers and Price of 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LY2033298
5mg
$ 215.00

Tocris
LY2033298 ≥98%(HPLC)
25
$ 759.00

Sigma-Aldrich
LY2033298 ≥98% (HPLC)
5mg
$ 289.00

Sigma-Aldrich
LY2033298 ≥98% (HPLC)
25mg
$ 1160.00

Crysdot
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide 95+%
1g
$ 950.00

Crysdot
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide 95+%
250mg
$ 380.00

Crysdot
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide 95+%
100mg
$ 238.00

Biosynth Carbosynth
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
50 mg
$ 294.00

Biosynth Carbosynth
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
25 mg
$ 185.00

Biosynth Carbosynth
3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide
10 mg
$ 100.00

Total 20 raw suppliers

Chemical Property of 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:534.7°C at 760 mmHg
Flash Point:277.177°C
PSA：108.97000
Density:1.475g/cm³
LogP:3.89710
Storage Temp.:-20°C
Solubility.:DMSO: >20mg/mL
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:311.0495256
Heavy Atom Count:20
Complexity:396

Purity/Quality:

97% ^*data from raw suppliers

LY2033298 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 43
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C2C(=C(SC2=NC(=C1Cl)OC)C(=O)NC3CC3)N
Uses LY2033298 is an allosteric potentiator.

Technology Process of 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide

There total 6 articles about 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1610591-81-5
3-amino-5-chloro-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylic acid

: 765-30-0
Cyclopropylamine

: 886047-13-8
LY 2033298

Guidance literature:: 3-amino-5-chloro-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

Cyclopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1039/c5md00334b

Reference yield:

: 1610591-79-1
ethyl 5-chloro-3-(1,3-dioxoisoindolin-2-yl)-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylate

: 886047-13-8
LY 2033298

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 1 h / Reflux

2.1: sodium hydroxide / ethanol / 1.5 h / Reflux

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1039/c5md00334b

Reference yield:

: 1610591-77-9
ethyl 3-amino-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxylate

: 886047-13-8
LY 2033298

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 36 h / Reflux

2.1: N-chloro-succinimide; hydrogenchloride / water; acetonitrile / 1.5 h / Inert atmosphere; Reflux

3.1: hydrazine hydrate / ethanol / 1 h / Reflux

4.1: sodium hydroxide / ethanol / 1.5 h / Reflux

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 20 °C

With hydrogenchloride; N-chloro-succinimide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c5md00334b