4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)

Base Information

Chemical Name:4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)
CAS No.:893428-72-3
Molecular Formula:2C₄H₄O₄*C₂₇H₃₂ClN₅O₅
Molecular Weight:774.181
Hs Code.:
Mol file:893428-72-3.mol

4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)

Synonyms:AZD 0530 difumarate; N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine Difumarate;Saracatinib difumarate;

Suppliers and Price of 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Axon Medchem
AZD0530difumarate-Saracatinibdifumarate 99%
25 mg
$ 220.00

American Custom Chemicals Corporation
SARACATINIB FUMARATE 95.00%
5MG
$ 272.80

Total 2 raw suppliers

Chemical Property of 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)

Chemical Property:

PSA：239.64000
LogP:3.31190

Purity/Quality:

99% ^*data from raw suppliers

AZD0530difumarate-Saracatinibdifumarate 99% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2)

There total 7 articles about 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, (2E)-2-butenedioate (1:2) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: saracatinib

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 893428-72-3
N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine difumarate

Guidance literature:: In water; isopropyl alcohol; at 70 - 75 ℃;
DOI:10.1021/op100163m

Reference yield: 72.0%

: 5464-12-0
2-(4-methylpiperazinyl)ethanol

: 379229-54-6
N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 893428-72-3
N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine difumarate

: 1241906-33-1
C₂₆H₃₂ClN₅O₅

Guidance literature:: N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine; With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.416667h; Large scale reaction;

2-(4-methylpiperazinyl)ethanol; In tetrahydrofuran; at 15 - 20 ℃; for 2.53333h; Large scale reaction;

(2E)-but-2-enedioic acid; In isopropyl alcohol; at 75 ℃; Large scale reaction;
DOI:10.1021/op100161y