N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

Base Information

Chemical Name:N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
CAS No.:379229-54-6
Molecular Formula:C₂₀H₁₈ClN₃O₅
Molecular Weight:415.833
Hs Code.:

Synonyms:N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

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Chemical Property of N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

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Technology Process of N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

There total 1 articles about N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 379229-54-6
N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: 95 percent / ethanol; CH₂Cl₂ / 0 °C

2.1: 94 percent / 2-methoxy-ethanol / 2 h / Heating

3.1: 98 percent / MgBr₂; pyridine / 1.5 h / Heating

4.1: NaH / dimethylformamide / 1 h / 20 °C

4.2: 83 percent / dimethylformamide / 1 h / 0 °C

5.1: 88 percent / PPh₃; DTAD / CH₂Cl₂ / 1 h / 20 °C

6.1: 100 percent / K₂CO₃; PhSH / 1-methyl-pyrrolidin-2-one / 0.58 h / 195 °C

7.1: 57 percent / pyridine / 2 h / 120 °C

8.1: 66 percent / PPh₃; CCl₄ / 1,2-dichloro-ethane / 2 h / 70 °C

9.1: 84 percent / propan-2-ol / 0.5 h / 80 °C

10.1: 97 percent / ammonia / methanol / 20 °C

With pyridine; tetrachloromethane; ammonia; sodium hydride; potassium carbonate; thiophenol; triphenylphosphine; magnesium bromide; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; 2-methoxy-ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol; 5.1: Mitsunobu reaction;
DOI:10.1021/jm060434q

Reference yield: 72.0%

: 5464-12-0
2-(4-methylpiperazinyl)ethanol

: 379229-54-6
N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 893428-72-3
N-(5-chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine difumarate

: 1241906-33-1
C₂₆H₃₂ClN₅O₅

Guidance literature:: N-(5-chloro-1,3-benzodioxolane-4-yl)-7-hydroxy-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine; With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.416667h; Large scale reaction;

2-(4-methylpiperazinyl)ethanol; In tetrahydrofuran; at 15 - 20 ℃; for 2.53333h; Large scale reaction;

(2E)-but-2-enedioic acid; In isopropyl alcohol; at 75 ℃; Large scale reaction;
DOI:10.1021/op100161y