Technology Process of Propanoic acid, 2,2-dimethyl-, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ester
There total 12 articles about Propanoic acid, 2,2-dimethyl-, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-fluoro-2-methyl-1H-indol-5-ol;
With
1,4-diaza-bicyclo[2.2.2]octane;
In
acetonitrile;
at 20 - 29 ℃;
for 1.16667h;
Large scale;
4-chloro-5-methylpyrrolo[1,2-f ][1,2,4]triazin-6-yl pivalate;
In
acetonitrile;
at 26 - 28 ℃;
for 3h;
Large scale;
DOI:10.1021/op400242j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / tetrahydrofuran / 7.75 h / 10 °C / Large scale
1.2: 5.5 h / 10 - 22 °C / Large scale
2.1: sulfuric acid / acetic acid / 6.42 h / 70 °C / Large scale
3.1: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale
4.1: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale
5.1: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale
6.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 1.17 h / 20 - 29 °C / Large scale
6.2: 3 h / 26 - 28 °C / Large scale
With
1,4-diaza-bicyclo[2.2.2]octane; aluminum (III) chloride; sodium dithionite; sulfuric acid; potassium tert-butylate; trimethylamine hydrochloride; potassium carbonate;
In
tetrahydrofuran; methanol; dichloromethane; water; acetic acid; acetonitrile;
5.1: |Reissert Indole Synthesis;
DOI:10.1021/op400242j
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trichlorophosphate / acetonitrile / 0.13 h / 23 - 24 °C / Large scale
1.2: 11.5 h / 22 - 85 °C / Large scale
2.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 1.17 h / 20 - 29 °C / Large scale
2.2: 3 h / 26 - 28 °C / Large scale
With
1,4-diaza-bicyclo[2.2.2]octane; trichlorophosphate;
In
acetonitrile;
DOI:10.1021/op400242j
