4-Fluoro-5-hydroxy-2-methylindole

Base Information

• Chemical Name: 4-Fluoro-5-hydroxy-2-methylindole
• CAS No.: 288385-88-6
• Molecular Formula: C9H8FNO
• Molecular Weight: 165.167
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00438485
• Nikkaji Number: J2.958.693D
• Wikidata: Q72479989
• Mol file: 288385-88-6.mol

Synonyms:4-Fluoro-5-hydroxy-2-methylindole;288385-88-6;4-fluoro-2-methyl-1H-indol-5-ol;1H-INDOL-5-OL, 4-FLUORO-2-METHYL-;MFCD07368140;SCHEMBL296024;DTXSID00438485;4-fluoro-5-hydroxy-2methylindole;UMWRMOYYUHIPDT-UHFFFAOYSA-N;BCP05449;CS-B0662;4-Fluoro-2-methyl-1H indol-5-ol;2-Methyl-4-fluoro-1H-indole-5-ol;4-fluoro-5-hydroxy-2-methyl indole;AKOS006284808;AC-1881;FS-2399;PB15868;SY030210;2-METHYL-4-FLUORO-5-HYDROXYINDOLE;AM20040099;FT-0658190;4-FLUORO-5-HYDROXY-2-METHYL-1H-INDOLE;4-fluoro-5-hydroxy-2-methylindole, AldrichCPR;A21366;EN300-140862;J-515387;Z1198172122

Chemical Property of 4-Fluoro-5-hydroxy-2-methylindole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.672
• Boiling Point: 327.324 °C at 760 mmHg
• PKA: 7.39±0.50(Predicted)
• Flash Point: 151.761 °C
• PSA: 36.02000
• Density: 1.367 g/cm³
• LogP: 2.32100
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 165.058992041
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-5-hydroxy-2-methylindole 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(N1)C=CC(=C2F)O

Technology Process of 4-Fluoro-5-hydroxy-2-methylindole

There total 17 articles about 4-Fluoro-5-hydroxy-2-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

1-(2-fluoro-3-benzyloxy-6-nitrophenyl)-2-methoxypropene → 4-fluoro-2-methyl-1H-indol-5-ol (288385-88-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 55 - 60 ℃; for 4h; under 1500.15 - 2250.23 Torr; Autoclave;

Reference yield: 91.0%

1-(2-fluoro-3-benzyloxy-6-nitrophenyl)-2-ethoxypropene → 4-fluoro-2-methyl-1H-indol-5-ol (288385-88-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 45 - 50 ℃; for 6h; under 2250.23 - 3000.3 Torr; Autoclave;

Reference yield: 89.7%

1-(2-fluoro-3-(4-methoxybenzyloxy)-6-nitrophenyl)-2-methoxypropene → 4-fluoro-2-methyl-1H-indol-5-ol (288385-88-6)

Guidance literature:

With hydrogen; In acetonitrile; at 50 - 55 ℃; for 5h; under 2250.23 - 3000.3 Torr; Autoclave;

upstream raw materials:

1-(3-benzyloxy-2-fluoro-6-nitro-phenyl)-propan-2-one

1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

2-methyl-4-fluoro-5-methoxy-1H-indole

2,3,4-trifluoronitrobenzene

Downstream raw materials:

6-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yl pivalate

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol

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