3-Phenyl-3-methylpiperidine-2,6-dione

Base Information

• Chemical Name: 3-Phenyl-3-methylpiperidine-2,6-dione
• CAS No.: 14149-35-0
• Molecular Formula: C12H13 N O2
• Molecular Weight: 203.241
• Hs Code.: 2925190090
• Mol file: 14149-35-0.mol

Synonyms:Glutarimide,2-methyl-2-phenyl- (6CI,8CI); 2-Methyl-2-phenylglutarimide;3-Methyl-3-phenyl-2,6-piperidinedione; a-Methyl-a-phenylglutarimide; a-Phenyl-a-methylglutarimide

Chemical Property of 3-Phenyl-3-methylpiperidine-2,6-dione

Chemical Property:

• Vapor Pressure: 4.51E-06mmHg at 25°C
• Boiling Point: 383.1°C at 760 mmHg
• Flash Point: 164°C
• PSA: 49.66000
• Density: 1.141g/cm³
• LogP: 1.65680

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyl-3-methylpiperidine-2,6-dione

There total 19 articles about 3-Phenyl-3-methylpiperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-cyano-4-phenylpentanamide → (+/-)-3-Methyl-3-phenyl-2,6-piperidinedione (14149-35-0)

Guidance literature:

With IrH₅(P-(i-Pr)3)2; water;

DOI:10.1002/anie.200351689

Reference yield: 94.0%

acrylonitrile (107-13-1,25014-41-9) + 1-phenylethyl cyanide (1823-91-2) → (+/-)-3-Methyl-3-phenyl-2,6-piperidinedione (14149-35-0)

Guidance literature:

With IrH₅(P-(i-Pr)3)2; water; In tetrahydrofuran; at 150 ℃; for 20h;

DOI:10.1002/anie.200351689

Reference yield: 90.0%

(+)-4-Cyano-4-methyl-4-phenyl-butyric acid (1135-74-6,51439-66-8,51447-21-3,51447-23-5) → (-)-3-Methyl-3-phenyl-2,6-piperidinedione (14149-35-0,90355-53-6,90355-63-8,90355-64-9)

Guidance literature:

With sulfuric acid; In acetic acid; at 100 ℃; for 0.666667h;

DOI:10.1002/ardp.19843170413

upstream raw materials:

Methyl 4-cyano-4-methyl-4-phenyl-butyrate

2-methyl-2-phenyl-pentanedinitrile

4-Cyano-4-methyl-4-phenyl-butyric acid

acrylonitrile

Downstream raw materials:

1,3-Dimethyl-3-phenyl-2,6-piperidinedione

3-methyl-3-(4-aminophenyl)piperidine-2,6-dione

3-methyl-3-(4-nitrophenyl)piperidine-2,6-dione

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