5-Bromo-6-fluoropyridin-2-amine

Base Information

• Chemical Name: 5-Bromo-6-fluoropyridin-2-amine
• CAS No.: 944401-65-4
• Molecular Formula: C5H4BrFN2
• Molecular Weight: 191.003
• Hs Code.: 2933399990
• European Community (EC) Number: 832-808-1
• DSSTox Substance ID: DTXSID70697426
• Wikidata: Q72456448
• Mol file: 944401-65-4.mol

Synonyms:5-BROMO-6-FLUOROPYRIDIN-2-AMINE;944401-65-4;6-Amino-3-bromo-2-fluoropyridine;2-Amino-5-Bromo-6-fluoropyridine;5-bromo-6-fluoro-pyridin-2-ylamine;5-bromo-6-fluoro-2-pyridinamine;MFCD11848480;5-bromo-6-fluoro-2-pyridylamine;SCHEMBL319387;DTXSID70697426;SJXWFNBZBXZDCL-UHFFFAOYSA-N;AMY42506;AKOS016011715;SB18617;5-bromanyl-6-fluoranyl-pyridin-2-amine;AS-50839;SY244810;CS-0040534;EN300-194801;P11228;A844953;J-517126

Chemical Property of 5-Bromo-6-fluoropyridin-2-amine

Chemical Property:

• Boiling Point: 245℃
• PKA: 1.25±0.10(Predicted)
• Flash Point: 102℃
• PSA: 39.64000
• Density: 1.813
• LogP: 1.49550
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 189.95419
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

97% ^*data from raw suppliers

5-bromo-6-fluoropyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1Br)F)N
• Uses: 2-Amino-5-bromo-6-fluoropyridine is an organic intermediate, which can be prepared by bromination of 6-fluoropyridin-2-amine.

Technology Process of 5-Bromo-6-fluoropyridin-2-amine

There total 3 articles about 5-Bromo-6-fluoropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-fluoro-pyridin-2-ylamine (1597-32-6) → 5-bromo-6-fluoropyridin-2-ylamine (944401-65-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 0 ℃; for 3h; Inert atmosphere;

Reference yield: 60.0%

→ 5-bromo-6-fluoropyridin-2-ylamine (944401-65-4)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 5 - 20 ℃;

Reference yield:

3-bromo-2,6-difluoro-pyridine (80392-79-6) → 5-bromo-6-fluoropyridin-2-ylamine (944401-65-4)

Guidance literature:

With ammonia; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 180 ℃; for 2h;

DOI:10.1016/j.bmcl.2015.07.023

upstream raw materials:

6-fluoro-pyridin-2-ylamine

3-bromo-2,6-difluoro-pyridine

Downstream raw materials:

6-amino-2-fluoronicotinic acid methyl ester

6-fluoro-5-(4-(2-oxo-2-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-amine

5-bromo-6-phenoxypyridin-2-amine

N-(5-(4-chlorophenyl)-6-phenoxypyridin-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide