1597-32-6

Basic information

• Product Name: 2-Amino-6-fluoropyridine
• Synonyms: 2-AMINO-6-FLUOROPYRIDINE;6-FLUORO-PYRIDIN-2-YLAMINE;4''-ETHOXY-2,2,2-TRIFLUOROACETOPHENONE;6-Fluoropyridin-2-amine;2-AMino-6-fluoropyriMidine;2-AMino-6-fluoropyridine, 97+%;EOS-60628
• CAS NO: 1597-32-6
• Molecular Formula: C₅H₅FN₂
• Molecular Weight: 112.11
• Product Categories: Pyridine;Pyridines;Fluorine series
• Mol File: 1597-32-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 59-61°C
• Boiling Point: 224.977 °C at 760 mmHg
• Flash Point: 89.863 °C
• Appearance: /
• Density: 1.257 g/cm³
• Vapor Pressure: 0.0165mmHg at 25°C
• Refractive Index: 1.452
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 2.26±0.24(Predicted)
• CAS DataBase Reference: 2-Amino-6-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-fluoropyridine(1597-32-6)
• EPA Substance Registry System: 2-Amino-6-fluoropyridine(1597-32-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1597-32-6(Hazardous Substances Data)

Usage

Description

2-Amino-6-fluoropyridine is a chemical compound with a unique structural composition, featuring a fluorine atom and an amino group attached to a pyridine ring in the meta position. It has the molecular formula C5H5FN2 and is known for its applications in the synthesis of pharmaceuticals, agrochemicals, and materials science for the creation of organic semiconductors and optoelectronic devices. Due to its potential for skin, eye, and respiratory tract irritation, it is important to handle this compound with care.

Uses

Used in Pharmaceutical Industry:
2-Amino-6-fluoropyridine is used as a key intermediate in the synthesis of various pharmaceutical products. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-Amino-6-fluoropyridine is used as a building block in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Materials Science:
2-Amino-6-fluoropyridine is used as a component in the creation of organic semiconductors and optoelectronic devices, due to its electronic properties and potential for use in advanced materials.

InChI:InChI=1/C10H9F3O2/c1-2-15-8-5-3-7(4-6-8)9(14)10(11,12)13/h3-6H,2H2,1H3

Upstream product

• 1075-62-3 N-(6-aminopyridin-2-yl)acetamide 
• 1513-65-1 2,6-difluoro pyridine 
• 258343-71-4 N-(6-fluoropyridin-2-yl)acetamide 

Downstream Products

• 878197-91-2 2-(dichloromethyl)-5-fluoroimidazo[1,2-a]pyridine 
• 1355326-84-9 C₂₈H₃₀F₂N₄O₂ 
• 1354284-18-6 2-(3,5-difluorophenyl)-3-methyl-N-(6-morpholinopyridin-2-yl)-1,8-naphthyridin-4-amine 
• 1258532-04-5 N,N'-(1,4-phenylenebis(methylene))bis(6-fluoropyridin-2-amine) 
• 898195-98-7 MSX-222 
• 1208552-63-9 C₁₆H₁₆ClFN₂O 
• 1208372-52-4 2-(3,4-dichloro-phenyl)-quinoline-4-carboxylic acid (6-fluoro-pyridin-2-yl)-amide 
• 1208372-55-7 2-(4-chloro-phenyl)-quinoline-4-carboxylic acid (6-fluoro-pyridin-2-yl)-amide 
• 1208372-60-4 2-(3,4-dimethoxy-phenyl)-quinoline-4-carboxylic acid (6-fluoro-pyridin-2-yl)-amide 
• 1208372-58-0 2-(4-methoxy-phenyl)-quinoline-4-carboxylic acid (6-fluoro-pyridin-2-yl)-amide 
• 1196661-93-4 (2-chlorobenzyl)(6-fluoropyridin-2-yl)amine 
• 1187324-63-5 1-(4-fluorophenyl)-N-(6-fluoro-2-pyridinyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide 
• 944401-65-4 5-bromo-6-fluoropyridin-2-ylamine 
• 878197-67-2 5-fluoroimidazo[1,2-a]pyridine-2-carbaldehyde 

Relevant articles and documents

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1

Stereorandom and diastereoselective syntheses of a novel 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system are described. Derivatives of all four diastereomers were prepared and isolated in >98% ee. The pure enantiomers were compared in order t

7-Azaindole derivatives as potential partial nicotinic agonists

We have investigated a series of 7-azaindoles as potential partial agonists of the α4β2 nicotinic acetylcholine receptor (nAChR). Three series of 7-azaindole derivatives have been synthesized and evaluated for rat brain neuronal nicotinic receptor affinity and functional activity. Compound (+)-51 exhibited the most potent nAChR binding (Ki = 10 nM). Compound 30A demonstrated both moderate binding affinity and partial agonist potency, thus representing a promising lead for the indications of cognition and smoking cessation.