5-bromo-2-p-tolylpyridine

Base Information

• Chemical Name: 5-bromo-2-p-tolylpyridine
• CAS No.: 867380-38-9
• Molecular Formula: C₁₂H₁₀BrN
• Molecular Weight: 248.122
• Hs Code.: 2933399090
• Mol file: 867380-38-9.mol

Synonyms:5-bromo-2-p-tolylpyridine;

Chemical Property of 5-bromo-2-p-tolylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 3.81950
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-(p-tolyl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-p-tolylpyridine

There total 5 articles about 5-bromo-2-p-tolylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,5-dibromopyridine (624-28-2) + 4-methylphenylboronic acid (5720-05-8) → 5-bromo-2-(4-methylphenyl)pyridine (867380-38-9)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In methanol; acetonitrile; at 50 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2013.10.065

Reference yield: 72.0%

2,5-dibromopyridine (624-28-2) + para-bromotoluene (106-38-7) → 5-bromo-2-(4-methylphenyl)pyridine (867380-38-9)

Guidance literature:

With sodium tetrachloropalladate(II); tetrahydroxydiboron; sodium dodecyl-sulfate; tricyclohexylphosphine tetrafluoroborate; sodium hydroxide; In water; at 60 - 100 ℃; for 12h; regioselective reaction;

DOI:10.1039/c8nj02184h

Reference yield: 50.0%

2,5-dibromopyridine (624-28-2) + di(p-tolyl)zinc (15106-88-4) → 5-bromo-2-(4-methylphenyl)pyridine (867380-38-9)

Guidance literature:

With C₆₀H₄₈Cl₂FeP₄; In tetrahydrofuran; toluene; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.1039/b915945b

upstream raw materials:

2,5-dibromopyridine

para-bromotoluene

di(p-tolyl)zinc

3-Bromopyridine