4-(2-chloropyridin-3-yl)morpholine

Base Information

• Chemical Name: 4-(2-chloropyridin-3-yl)morpholine
• CAS No.: 54231-44-6
• Molecular Formula: C9H11ClN2O
• Molecular Weight: 198.652
• Hs Code.: 2934999090
• Mol file: 54231-44-6.mol

Synonyms:4-(2-Chloro-pyridin-3-yl)-morpholine;2-chloro-3-morpholinopyridine;2-chloro-3-(morpholin-4-yl)pyridine;

Chemical Property of 4-(2-chloropyridin-3-yl)morpholine

Chemical Property:

• Boiling Point: 332.7℃
• Flash Point: 155℃
• PSA: 25.36000
• Density: 1.257
• LogP: 1.63660
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-chloropyridin-3-yl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-chloropyridin-3-yl)morpholine

There total 7 articles about 4-(2-chloropyridin-3-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-(benzoyloxy)morpholine (5765-65-1) + C10H13BClNO2 (1380288-32-3) → 2-chloro-3-(morpholin-4-yl)pyridine (54231-44-6)

Guidance literature:

With copper(I) triflate benzene complex; cesium fluoride; 1,1'-(oxydi-2,1-phenylene)bis[1,1-dicyclohexylphosphine]; In tetrahydrofuran; at 66 ℃; Inert atmosphere;

DOI:10.1039/c5cc03565a

Reference yield: 84.0%

morpholine (110-91-8,99108-56-2) + 2-chloro-3-iodopyridine (78607-36-0) → 2-chloro-3-(morpholin-4-yl)pyridine (54231-44-6)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 17h; Heating;

DOI:10.1021/jo049774e

Reference yield: 81.0%

morpholine (110-91-8,99108-56-2) + 3-bromo-2-chloropyridine (52200-48-3) → 2-chloro-3-(morpholin-4-yl)pyridine (54231-44-6)

Guidance literature:

With dichloro[4,5-bis(diphenylphosphino)-9,9’-dimethylxanthene]palladium(II); sodium t-butanolate; at 75 ℃; Inert atmosphere;

DOI:10.1002/chem.201902147

upstream raw materials:

4-(2-nitropyridin-3-yl)morpholine

morpholine

2-chloro-3-iodopyridine

3-chloro-2-nitropyridine

Downstream raw materials:

N-(4-(3-morpholinopyridin-2-yloxy)phenyl)benzo[d]thiazol-2-amine

4-(2-[4-(3,4-dimethoxypyridin-2-yl)methoxyphenyl]pyridin-3-yl)morpholine