cis-cyclohexane-1,3-diamine hydrochloride

Base Information

• Chemical Name: cis-cyclohexane-1,3-diamine hydrochloride
• CAS No.: 28294-92-0
• Molecular Formula: C₆H₁₄N₂*2ClH
• Molecular Weight: 187.112
• Mol file: 28294-92-0.mol

Synonyms:1,3-cyclohexanediamine hydrochloride;cyclohexane-1,3-diamine hydrochloride;

Chemical Property of cis-cyclohexane-1,3-diamine hydrochloride

Chemical Property:

• PSA: 52.04000
• LogP: 2.41760

Purity/Quality:

98%min ^*data from raw suppliers

Cyclohexane-1,3-diaminedihydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-cyclohexane-1,3-diamine hydrochloride

There total 2 articles about cis-cyclohexane-1,3-diamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

(1R,3S)-cyclohexane-1,3-diamine (26772-34-9) → cis-cyclohexane-1,3-diamine dihydrochloride (28294-92-0,32175-26-1,498532-32-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/j.bmcl.2013.09.016

Reference yield:

1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) → cis-cyclohexane-1,3-diamine dihydrochloride (28294-92-0,32175-26-1,498532-32-4)

Guidance literature:

Multi-step reaction with 2 steps

1: nickel(II) chloride hexahydrate

2: hydrogenchloride

With hydrogenchloride; nickel(II) chloride hexahydrate;

DOI:10.1016/j.bmcl.2013.09.016

Reference yield:

cis-cyclohexane-1,3-diamine dihydrochloride (28294-92-0,32175-26-1,498532-32-4) → C22H28N2O2

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide

2: sodium tetrahydroborate / chloroform / 33 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane

4: trifluoroacetic acid / dichloromethane

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2013.09.016

upstream raw materials:

1,3-diaminocyclohexane

(1R,3S)-cyclohexane-1,3-diamine

Refernces