26772-34-9

Basic information

• Product Name: (1R,3S)-1β,3β-Cyclohexanediamine
• Synonyms: (1R,3S)-1,3-Cyclohexanediamine;(1R,3S)-1β,3β-Cyclohexanediamine;(1S)-1α,3α-Cyclohexanediamine;cis-1,3-CyclohexanediaMine;cis-1,3-Diaminocyclohexane;cis-1,3-Cyclohexanediamine;cis-cyclohexane-1,3-diamine;[(1R，3S)-3-AZANIUMYLCYCLOHEXYL]AZANIUM
• CAS NO: 26772-34-9
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.18876
• Mol File: 26772-34-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 198°C(lit.)
• Appearance: /
• Density: 0.9515 g/cm3
• Refractive Index: 1.4890-1.4930
• PKA: 10.70±0.70(Predicted)
• CAS DataBase Reference: (1R,3S)-1β,3β-Cyclohexanediamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,3S)-1β,3β-Cyclohexanediamine(26772-34-9)
• EPA Substance Registry System: (1R,3S)-1β,3β-Cyclohexanediamine(26772-34-9)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 26772-34-9(Hazardous Substances Data)

Usage

General Description

"(1R,3S)-1β,3β-Cyclohexanediamine" is a chemical compound that belongs to the class of organic compounds known as cyclohexanamines, which are compounds containing a cyclohexanamine moiety, a six-member, saturated aliphatic ring substituted by one amine group. Its systematic name is (1R,3S)-1,3-diaminocyclohexane. Because of its specific 3D structure, it can exhibit chirality, making it an interesting compound for chemical and pharmaceutical research. Although it is not extensively described in the literature, it likely shares some of the properties typical of diamines, including basicity and the ability to act as a ligand in complexation reactions.

Upstream product

• 99-09-2 3-nitro-aniline 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 
• 930-68-7 cyclohexenone 
• 108-45-2 m-phenylenediamine 
• 82166-21-0 methyl cyclohexane 
• 3385-21-5 1,3-diaminocyclohexane 
• 141-78-6 ethyl acetate 
• 10268-78-7 1,3-diacetylaminobenzene 
• 32189-20-1 trans-N,N'-bis(acetyl)cyclohexane-1,3-diamine 
• 2802-07-5 1,3-cyclohexanedionedioxime 
• 1634-04-4 tert-butyl methyl ether 
• 24424-99-5 di-tert-butyl dicarbonate 
• 174893-22-2 cis-1,3-cyclohexanedi(tert-butoxycarbonyl)amine 
• 32189-20-1 cis-N,N'-bis(acetyl)cyclohexane-1,3-diamine 

Downstream Products

• 1165952-91-9 cyclohexa-1,3-diene 
• 3385-21-5 trans-cyclohexane-1,3-diamine 
• 347186-01-0 N-(3-aminocyclohexyl)(t-butoxy)carboxamide 
• 645400-45-9 N-(6-methoxy-4-methylquinolin-2-yl)cyclohexane-1,3-diamine 
• 860297-18-3 2-[(3-aminocyclohexyl)amino]-N,N-dimethylquinoline-4-carboxamide 
• 860297-23-0 N₂-(3-aminocyclohexyl)-N₆,N₆-dimethylquinoline-2,6-diamine 
• 1000417-94-6 N-(6-chloroquinolin-2-yl)cyclohexane-1,3-diamine 
• 390765-51-2 tert-butyl 3-(2,4-dioxo-3,4, 5,6,7,8-hexahydro-1(2H)-quinazolinyl)cyclohexylcarbamate 
• 921590-99-0 N-(3-aminocyclohexyl)-5-[4-(benzyloxy)phenyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1016495-70-7 C₈H₁₆N₂O 
• 860351-60-6 (1S,3S)-cyclohexane-1,3-diamine 
• 3385-21-5 trans-1,3-cyclohexanediamine 
• 32189-20-1 trans-1,3-Diacetamido-cyclohexan 
• 860434-15-7 (+)-dibenzyl trans-cyclohexane-1,3-diylbiscarbamate 

Relevant articles and documents

Synthesis method of weather-resistant epoxy resin curing agent

The invention discloses a synthesis method of a weather-resistant epoxy resin curing agent. The method comprises the following steps of: enabling cyclohexanedicarboxylic acid and azidoformic acid 2, 2, 2-trichloroethyl ester to react under the catalysis of DMAP and copper acetate to generate an intermediate b, and enabling the intermediate b to react with potassium carbonate to generate 1, 3-bis (aminomethyl) cyclohexane. According to a traditional synthesis method of 1, 3-bis (aminomethyl) cyclohexane, m-xylylenediamine (MXDA) is subjected to benzene ring hydrogenation reduction to prepare the 1, 3-bis (aminomethyl) cyclohexane. The invention provides the novel synthesis method of 1, 3-bis (aminomethyl) cyclohexane (1, 3-BAC), and the method is simple in process.

Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators

A novel series of trans-1,3-cyclohexyl diamides was discovered and characterized as mGluR5 negative allosteric modulators (NAMs) lacking an alkyne moiety. Conformational constraint of one of the amide bonds in the diamide template led to a spirooxazoline template. A representative compound (24d) showed good in vitro potency, high CNS penetration and, upon subcutaneous dosing, demonstrated efficacy in the mouse marble burying test, generally used as indicative of potential anxiolytic activity.

Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists

We herein report the optimization of cyclopentane- and cyclohexane-1,3-diamine derivatives as novel and potent MCH-R1 antagonists. Structural modifications of the 2-amino-quinoline and thiophene moieties found in the initial lead compound served to improve its metabolic stability profile and MCH-R1 affinity, and revealed unprecedented SAR when compared to other 2-amino-quinoline-containing MCH-R1 antagonists.