4,6-DIMETHOXYPYRIMIDINE-2-CARBOXYLICACID

Base Information

• Chemical Name: 4,6-DIMETHOXYPYRIMIDINE-2-CARBOXYLICACID
• CAS No.: 128276-50-6
• Molecular Formula: C7H8N2O4
• Molecular Weight: 184.152
• Hs Code.: 2933599090
• Mol file: 128276-50-6.mol

Synonyms:4,6-DIMETHOXYPYRIMIDINE-2YL-CARBOXYLICACID;2-PyriMidinecarboxylic acid, 4,6-diMethoxy-;2-Carboxy-4,6-dimethoxypyrimidine

Chemical Property of 4,6-DIMETHOXYPYRIMIDINE-2-CARBOXYLICACID

Chemical Property:

• Vapor Pressure: 5.04E-08mmHg at 25°C
• Melting Point: 156～158℃
• Boiling Point: 426.2°C at 760 mmHg
• Flash Point: 211.6°C
• PSA: 81.54000
• Density: 1.349g/cm³
• LogP: 0.19200
• Storage Temp.: 2-8°C

Purity/Quality:

98+% ^*data from raw suppliers

4,6-Dimethoxypyrimidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DIMETHOXYPYRIMIDINE-2-CARBOXYLICACID

There total 1 articles about 4,6-DIMETHOXYPYRIMIDINE-2-CARBOXYLICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4,6-dimethoxy-2-pyrimidinecarboxylate (128276-49-3) → 4,6-dimethoxypyrimidine-2-carboxylic acid (128276-50-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In ethanol; dichloromethane; water;

Reference yield: 89.0%

4,6-dimethoxypyrimidine-2-carboxylic acid (128276-50-6) + (4E)-4-[3-(3-chlorophenyl)prop-2-ynylidene]-3,3-dimethylpiperidine → {(4E)-4-[3-(3-chlorophenyl)prop-2-yn-1-ylidene]-3,3-dimethylpiperidin-1-yl}(1,6-dimethoxypyrimidin-2-yl)methanone

Guidance literature:

With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

4,6-dimethoxypyrimidine-2-carboxylic acid (128276-50-6) + (5S)-5-benzyl-2,4-dioxo-3-[(1R)-1-phenylethyl]-1,3-oxazolidine-5-carbohydrazide (1430086-21-7) → C26H25N5O7

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmcl.2014.02.057

upstream raw materials:

ethyl 4,6-dimethoxy-2-pyrimidinecarboxylate

Downstream raw materials:

4,6-dimethoxypyrimidine-2-carbonylchloride