1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride

Base Information

• Chemical Name: 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride
• CAS No.: 1121057-75-7
• Molecular Formula: C11H20BNO2.ClH
• Molecular Weight: 245.557
• Hs Code.: 2934999090
• Mol file: 1121057-75-7.mol

Synonyms:1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine hydrochloride;1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacolester, hydrochloride.;1,2,3,6-Tetrahydropyridine-4-boronic acid, pinacol ester, HCl

Chemical Property of 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride

Chemical Property:

• PSA: 30.49000
• LogP: 2.66830
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is a useful synthetic intermediate. It was used in the synthesis of N-arylheterocycles as MCH antagonists. It can also be used as a reagent to prepare substituted imidazopyridine derivatives and analogs for use as antiviral agents.

Technology Process of 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride

There total 1 articles about 1,2,3,6-Tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride (1121057-75-7)

Guidance literature:

With hydrogenchloride; In tert-butyl methyl ether; at 20 ℃;

Reference yield: 100.0%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride (1121057-75-7) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate (286961-15-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 87.0%

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine hydrochloride (1121057-75-7) + acetyl chloride (75-36-5) → 1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethan-1-one (1227068-67-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

upstream raw materials:

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Downstream raw materials:

benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethan-1-one

1-methanesulfonyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine

cyclopropyl-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]methanone

Refernces

• 1、 -. "HERBICIDAL PYRIDINIUM COMPOUNDS". Page/Page column 75. . Retrieved 2020/08/22.
• 2、 -. "NOVEL COMPOUNDS". Page/Page column 37; 38. . Retrieved 2019/03/05.