5,6-Difluorobenzo[c][1,2,5]oxadiazole 1-oxide

Base Information

• Chemical Name: 5,6-Difluorobenzo[c][1,2,5]oxadiazole 1-oxide
• CAS No.: 171111-70-9
• Molecular Formula: C6H2F2N2O2
• Molecular Weight: 172.091
• Mol file: 171111-70-9.mol

Synonyms:5,6-Difluorobenzo[c][1,2,5]oxadiazole 1-oxide;5,6-Difluoro-2,1,3-benzoxadiazole 1-oxide;5,6-Difluorobenzofurazan 1-oxide;5,6-Difluorobenzofuroxan

Chemical Property of 5,6-Difluorobenzo[c][1,2,5]oxadiazole 1-oxide

Chemical Property:

• Melting Point: 140-147℃
• PSA: 51.49000
• LogP: 1.53450

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-Difluorobenzo[c][1,2,5]oxadiazole 1-oxide

There total 5 articles about 5,6-Difluorobenzo[c][1,2,5]oxadiazole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.4%

4,5-difluoro-2-nitroaniline (78056-39-0) → 5,6-difluorobenzofuroxan (171111-70-9)

Guidance literature:

With sodium hypochlorite solution; sodium hydroxide; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield: 81.0%

4,5-Difluoro-2-nitrophenyl azide (216254-45-4) → 5,6-difluorobenzofuroxan (171111-70-9)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; In methanol; at 5 ℃;

DOI:10.1016/S0022-1139(03)00011-3

Reference yield:

3,4-difluoroacetanilide (458-11-7) → 5,6-difluorobenzofuroxan (171111-70-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 24 percent / HNO₃ / acetic acid / 4 h / 90 °C

2: 58 percent / CF₃CO₂H; NaNO₂; aq. NaN₃ / H₂SO₄ / 15 °C

3: 40 percent / acetic acid / 6 h / 100 - 110 °C

With sodium azide; nitric acid; trifluoroacetic acid; sodium nitrite; sulfuric acid; In acetic acid;

DOI:10.1016/S0022-1139(03)00011-3

upstream raw materials:

4,5-difluoro-2-nitroaniline

4,5-Difluoro-2-nitrophenyl azide

3,4-difluoroacetanilide

3,4-difluoroaniline

Downstream raw materials:

6,7-difluoro-3-methyl-1,4-dioxy-quinoxaline-2-carboxylic acid phenylamide

(6,7-difluoro-3-methyl-1,4-dioxy-quinoxalin-2-yl)-phenyl-methanone

6,7-difluoro-2-methyl-3-phenylsulfanyl-quinoxaline 1,4-dioxide

6,7-difluoro-3-phenylquinoxaline-2-carbonitrile 1,4-dioxide