ethyl 6-chloropyrimidine-4-carboxylate

Base Information

• Chemical Name: ethyl 6-chloropyrimidine-4-carboxylate
• CAS No.: 51940-63-7
• Molecular Formula: C7H7ClN2O2
• Molecular Weight: 186.598
• Hs Code.: 2933599090
• Mol file: 51940-63-7.mol

Synonyms:Ethyl 6-chloropyrimidine-4-carboxylate; 6-Chloro-4-pyrimidine carbocylic acid ethyl ester; 6-Chloro-pyrimidine-4-carboxylic acid ethyl ester; ethyl-6-chloropyrimidine-4-carboxylate; Ethyl 6-chloro-4-pyrimidinecarboxylate; 4-Pyrimidinecarboxylic acid, 6-chloro-, ethyl ester; 6-Chloro-4-pyriMidinecarboxylic acid ethyl ester

Chemical Property of ethyl 6-chloropyrimidine-4-carboxylate

Chemical Property:

• Boiling Point: 284.5±20.0 °C(Predicted)
• PKA: -2.89±0.17(Predicted)
• PSA: 52.08000
• Density: 1.311±0.06 g/cm3(Predicted)
• LogP: 1.30670
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl6-Chloropyrimidine-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 6-chloropyrimidine-4-carboxylate

There total 6 articles about ethyl 6-chloropyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 6-hydroxypyrimidine-4-carboxylate → ethyl 6-chloropyrimidine-4-carboxylate (51940-63-7)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In ethyl acetate; at 75 ℃; Inert atmosphere;

Reference yield: 95.0%

6-chloropyrimidine-4-carbonyl chloride (263270-52-6) + ethanol (64-17-5) → ethyl 6-chloropyrimidine-4-carboxylate (51940-63-7)

Guidance literature:

In dichloromethane; at 20 ℃;

Reference yield: 38.0%

ethanol (64-17-5) + 6-hydroxypyrimidine-4-carboxylic acid (6299-87-2) → ethyl 6-chloropyrimidine-4-carboxylate (51940-63-7)

Guidance literature:

6-hydroxypyrimidine-4-carboxylic acid; With phosphorus pentachloride; trichlorophosphate; for 12h; Reflux;

ethanol; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/j.ejmech.2018.02.042

upstream raw materials:

6-chloropyrimidine-4-carbonyl chloride

ethanol

6-hydroxypyrimidine-4-carboxylic acid

acetylenedicarboxylic acid diethyl ester

Downstream raw materials:

ethyl 6-(phenylamino)pyrimidine-4-carboxylate

6-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid-[2-(2-fluoro-phenyl)-ethyl]-amide

7-methoxy-3-{1-[6-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-carbonyl)-pyrimidin-4-yl]-piperidin-4-yl}-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one

6-[4-(7-methoxy-2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid-phenylamide

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