N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos

Base Information

• Chemical Name: N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos
• CAS No.: 1237588-12-3
• Molecular Formula: C30H42NOP
• Molecular Weight: 463.643
• Mol file: 1237588-12-3.mol

Synonyms:Mor-DalPhos;Di(1-adamantyl)-2-morpholinophenylphosphine;N-(2-(di(1-adamantyl)phosphino)phenyl)morpholine;Bis(adamant-1-yl)(2-morpholinophenyl)phosphine;

Chemical Property of N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos

Chemical Property:

• Melting Point: 219-224°C
• PKA: 4.75±0.40(Predicted)
• PSA: 26.06000
• LogP: 6.63300
• Storage Temp.: 2-8°C
• Sensitive.: air sensitive

Purity/Quality:

97% ^*data from raw suppliers

Mor-DalPhos ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Mor-DalPhos is a versatile and efficient green catalytic system for Buchwald-Hartwig cross-coupling reaction of aryl bromides or chlorides with a large set amines, amides, ureas, and carbamates. MorDalphos is an electronically rich, sterically hindered P,N-based ancillary ligand developed by the Stradiotto group that can be used in the Buchwald-Hartwig Amination reaction, alkyne hydroamination and monoarylation of compounds such as ammonia, hydrazine, and acetone.

Technology Process of N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos

There total 1 articles about N-[2-(di-1-adamantylphosphino) phenyl]morpholine,98% Mor-DalPhos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-(2-bromophenyl)morpholine (87698-82-6) + di-1-adamantylphosphine (131211-27-3) → N-(2-(di(1-adamantyl)phosphino)phenyl)morpholine (1237588-12-3)

Guidance literature:

With 1,1'-bis(diisopropylphosphino)ferrocene; palladium diacetate; sodium t-butanolate; In toluene; at 110 ℃; Inert atmosphere;

DOI:10.1002/anie.201000526

Reference yield: 100.0%

chloro(dimethylsulfide) gold(I) (29892-37-3) + N-(2-(di(1-adamantyl)phosphino)phenyl)morpholine (1237588-12-3) → Mor-DaIPhos-AuCl (1259987-95-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/adsc.201300855

Reference yield: 94.0%

dihydrogen tetrachloropalladate(II) + N-(2-(di(1-adamantyl)phosphino)phenyl)morpholine (1237588-12-3) → [HMorDalPhos]2[Pd2Cl6]

Guidance literature:

In acetone; at 18 - 27 ℃; for 1.83333h;

upstream raw materials:

4-(2-bromophenyl)morpholine

di-1-adamantylphosphine

Downstream raw materials:

Au(P(C₁₀H₁₅)2C₆H₄NC₄H₈O)(C₆H₁₀)⁽¹⁺⁾*B(C₆F₅)4^(1-)=Au(P(C₁₀H₁₅)2C₆H₄NC₄H₈O)(C₆H₁₀)B(C₆F₅)4

Au(P(C₁₀H₁₅)2C₆H₄NC₄H₈O)(NHC₄H₈O)⁽¹⁺⁾*B(C₆F₅)4^(1-)=Au(P(C₁₀H₁₅)2C₆H₄NC₄H₈O)(NHC₄H₈O)B(C₆F₅)4

Pd((NC₄H₈O)C₆H₄P(C₁₀H₁₅)2)(C₆H₅C₂C₆H₅)

Pd((NC₄H₈O)C₆H₄P(C₁₀H₁₅)2)Br(C₆H₄C₂C₆H₅)