4-(2-Bromophenyl)morpholine

Base Information

• Chemical Name: 4-(2-Bromophenyl)morpholine
• CAS No.: 87698-82-6
• Molecular Formula: C10H12BrNO
• Molecular Weight: 242.115
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20416043
• Nikkaji Number: J909.648E
• Mol file: 87698-82-6.mol

Synonyms:4-(2-bromophenyl)morpholine;87698-82-6;2-bromophenylmorpholine;N-(2-Bromophenyl)morpholine;6-bromophenyl morpholine;SCHEMBL136220;DTXSID20416043;SGUXGSGHYOGBDH-UHFFFAOYSA-N;AMY32760;MFCD03086182;AKOS015835087;DS-17143;CS-0028782;FT-0686452;S11032;A862461;InChI=1/C10H12BrNO/c11-9-3-1-2-4-10(9)12-5-7-13-8-6-12/h1-4H,5-8H

Chemical Property of 4-(2-Bromophenyl)morpholine

Chemical Property:

• Boiling Point: 324.8±37.0 °C(Predicted)
• PKA: 4.47±0.40(Predicted)
• PSA: 12.47000
• Density: 1.433±0.06 g/cm3(Predicted)
• LogP: 2.35070
• Storage Temp.: Room temperature.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 241.01023
• Heavy Atom Count: 13
• Complexity: 159

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Bromophenyl)morpholine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=CC=C2Br

Technology Process of 4-(2-Bromophenyl)morpholine

There total 9 articles about 4-(2-Bromophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Phenylmorpholine (92-53-5) → 4-bromophenyl-morpholine (30483-75-1) + 4-(2-bromophenyl)morpholine (87698-82-6)

Guidance literature:

With dihydrogen peroxide; sodium bromide; tetraethoxy orthosilicate; 3-aminopropyltriethoxysilane; In 1,4-dioxane; phosphate buffer; for 24h;

DOI:10.1021/jo801234e

Reference yield: 83.0%

morpholine (110-91-8,99108-56-2) + 1-Bromo-2-iodobenzene (583-55-1) → 4-(2-bromophenyl)morpholine (87698-82-6)

Guidance literature:

With 18-crown-6 ether; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; for 25h; Ambient temperature;

DOI:10.1021/jo970876x

Reference yield: 78.0%

morpholine (110-91-8,99108-56-2) + 2-bromophenyl nonafluorobutane-1-sulfonate → 4-(2-bromophenyl)morpholine (87698-82-6)

Guidance literature:

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 105 ℃; for 24h;

DOI:10.1021/jo034962a

upstream raw materials:

1,1'-oxybis(2-bromo-ethane)

2-bromoaniline

morpholine

1-Bromo-2-iodobenzene

Downstream raw materials:

4-(2-(diphenylphosphino)phenyl)morpholine

2-(4-morpholino)benzonitrile

4-(2-iodophenyl)morpholine

N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(4-morpholinyl)phenyl]-1-benzothiophene-2-carboxamide hydrochloride