Z-D-ARG(MTR)-OH CHA

Base Information

• Chemical Name: Z-D-ARG(MTR)-OH CHA
• CAS No.: 210557-94-1
• Molecular Formula: C24H32N4O7S.C6H13N
• Molecular Weight: 619.77
• Mol file: 210557-94-1.mol

Synonyms:N-ALPHA-CARBOBENZOXY-N-OMEGA-(4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL)-D-ARGININE CYCLOHEXYLAMMONIUM SALT;N-ALPHA-CBZ-NG-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL-D-ARGININE CYCLOHEXYLAMMONIUM SALT;Z-D-ARG(MTR)-OH CHA;Z-N-OMEGA-(4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL)-D-ARGININE CYCLOHEXYLAMMONIUM SALT;cyclohexanamine (R)-2-(benzyloxycarbonylamino)-5-(3-(4-methoxy-2,3,6-trimethylphenylsulfonyl)guanidino)pentanoate;N-ALPHA-CBZ-N-GAMMA-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL-D-ARGININE CYCLOHEXYLAMMONIUM;N5-[Imino[[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]-N2-[(phenylmethoxy)carbonyl]-D-ornithine cyclohexanamine salt

Chemical Property of Z-D-ARG(MTR)-OH CHA

Chemical Property:

• Melting Point: 196-199°C
• PSA: 201.31000
• LogP: 6.91420
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%Min ^*data from raw suppliers

N5-[Imino[[(4-methoxy-2,3,6-trimethylphenyl)sulfonyl]amino]methyl]-N2-[(phenylmethoxy)carbonyl]-D-ornithineCyclohexylammoniumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-D-ARG(MTR)-OH CHA

There total 3 articles about Z-D-ARG(MTR)-OH CHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Arg-OH (1234-35-1) + cyclohexylamine (108-91-8,157973-60-9) + 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride (80745-07-9) → Z-Arg(Mtr)-OH*CHA (80745-09-1,210557-94-1)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1.) acetone, 3 h, 2.) ethyl acetate;

Reference yield:

2,3,5-trimethylanisole (20469-61-8) → Z-Arg(Mtr)-OH*CHA (80745-09-1,210557-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72.5 percent / chlorosulfonic acid / CH₂Cl₂ / -10 - -5 °C

2: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate

With chlorosulfonic acid; sodium hydroxide; In dichloromethane;

Reference yield:

2,3,5-trimethylphenol (697-82-5) → Z-Arg(Mtr)-OH*CHA (80745-09-1,210557-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99.8 percent / 60percent NaH in oil / dimethylsulfoxide / 10 h / Ambient temperature

2: 72.5 percent / chlorosulfonic acid / CH₂Cl₂ / -10 - -5 °C

3: 1.) 4 N NaOH / 1.) acetone, 3 h, 2.) ethyl acetate

With chlorosulfonic acid; sodium hydroxide; sodium hydride; In dichloromethane; dimethyl sulfoxide;

upstream raw materials:

Z-Arg-OH

cyclohexylamine

4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride

2,3,5-trimethylanisole

Refernces