Ethyl 4-oxotetrahydro-2H-pyran-2-carboxylate

Base Information

• Chemical Name: Ethyl 4-oxotetrahydro-2H-pyran-2-carboxylate
• CAS No.: 287193-07-1
• Molecular Formula: C8H12O4
• Molecular Weight: 172.17800
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID80708799
• Mol file: 287193-07-1.mol

Synonyms:Ethyl 4-oxotetrahydro-2H-pyran-2-carboxylate;287193-07-1;Ethyl 4-oxooxane-2-carboxylate;MFCD20922879;2H-Pyran-2-carboxylic acid, tetrahydro-4-oxo-, ethyl ester;Ethyl 4-Oxotetrahydropyran-2-carboxylate;4-Oxo-tetrahydro-pyran-2-carboxylic Acid Ethyl Ester;SCHEMBL5548895;DTXSID80708799;MECFFZNWFZDTRY-UHFFFAOYSA-N;AMY35256;DS-4337;SB40702;SY023354;CS-0049451;Ethyl4-oxotetrahydro-2H-pyran-2-carboxylate;FT-0725160;ethyl 4-oxo-tetrahydro-2H-pyran-2-carboxylate;P12863;A919081

Chemical Property of Ethyl 4-oxotetrahydro-2H-pyran-2-carboxylate

Chemical Property:

• Boiling Point: 84 °C(Press: 0.04 Torr)
• PSA: 52.60000
• Density: 1.162±0.06 g/cm3(Predicted)
• LogP: 0.29760
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 172.07355886
• Heavy Atom Count: 12
• Complexity: 188

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl4-Oxotetrahydro-2H-pyran-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1CC(=O)CCO1

Technology Process of Ethyl 4-oxotetrahydro-2H-pyran-2-carboxylate

There total 3 articles about Ethyl 4-oxotetrahydro-2H-pyran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-oxo-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester (287193-06-0) → 4-oxo-tetrahydro-pyran-2-carboxylic acid ethyl ester (287193-07-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

ethyl 4-oxo-4H-2-pyran-carboxylate (1551-45-7) → 4-oxo-tetrahydro-pyran-2-carboxylic acid ethyl ester (287193-07-1) + ethyl 4-hydroxytetrahydro-2H-pyran-2-carboxylate (1822505-24-7)

Guidance literature:

With ethanol; palladium;

Reference yield:

ethanol (64-17-5) → 4-oxo-tetrahydro-pyran-2-carboxylic acid ethyl ester (287193-07-1)

Guidance literature:

With sulfuric acid;

upstream raw materials:

ethyl 4-oxo-4H-2-pyran-carboxylate

ethanol

4-oxo-3,4-dihydro-2H-pyran-2-carboxylic acid ethyl ester

Refernces

• 1、 -. "IRAK INHIBITORS AND USES THEREOF". Paragraph 001250. . Retrieved 2013/07/25.
• 2、 -. "Modulators of Protein Tyrosine Phosphatases (PTPases)". Page/Page column 72. . Retrieved 2010/10/20.