1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl- (6CI,8CI,9CI)

Base Information

• Chemical Name: 1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl- (6CI,8CI,9CI)
• CAS No.: 6288-86-4
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.14
• Mol file: 6288-86-4.mol

Synonyms:1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl- (6CI,8CI,9CI);1-Methyl-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl- (6CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 0.0257mmHg at 25°C
• Refractive Index: 1.722
• Boiling Point: 255.7°C at 760 mmHg
• Flash Point: 108.4°C
• PSA: 43.60000
• Density: 1.39g/cm³
• LogP: 0.36330

Purity/Quality:

99% ^*data from raw suppliers

1-Methyl-1H-pyrazolo[3,4-d]pyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl- (6CI,8CI,9CI)

There total 4 articles about 1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl- (6CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 5-Amino-1-methylpyrazole (1192-21-8) → 1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one (6288-86-4)

Guidance literature:

With trichlorophosphate; In dichloromethane; at 80 - 90 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2012.11.002

Reference yield: 27.0%

1H-pyrazolo[3,4-d]pyrimidine (271-80-7,35760-86-2) + methyl iodide (74-88-4) → 1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one (6288-86-4) + 2-methyl-2Hpyrazolo[3,4-d]pyrimidine

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/acs.joc.8b00540

Reference yield:

4-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (23000-43-3) → 1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one (6288-86-4)

Guidance literature:

With palladium on activated charcoal; ammonia; Hydrogenation;

DOI:10.1021/jo01117a010

upstream raw materials:

4-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

formamide

5-Amino-1-methylpyrazole

1H-pyrazolo[3,4-d]pyrimidine

Downstream raw materials:

5-Benzoyl-1-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4-carbonitrile

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