6-Methyl-1H-indole-2,3-dione

Base Information

• Chemical Name: 6-Methyl-1H-indole-2,3-dione
• CAS No.: 1128-47-8
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.16
• Hs Code.: 2933990090
• Mol file: 1128-47-8.mol

Synonyms:6-Methylindoline-2,3-dione

Chemical Property of 6-Methyl-1H-indole-2,3-dione

Chemical Property:

• Melting Point: >147 °C
• PKA: 9.87±0.20(Predicted)
• PSA: 46.17000
• Density: 1.301g/cm³
• LogP: 1.26780
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

6-Methylisatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Methyl-1H-indole-2,3-dione

There total 27 articles about 6-Methyl-1H-indole-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(2-amino-4-methylphenyl)-N-hexyl-2-oxoacetamide → 6-methylindoline-2,3-dione (1128-47-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201600143

Reference yield: 87.0%

6-methylindole (3420-02-8) → 6-methylindoline-2,3-dione (1128-47-8)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In dimethyl sulfoxide; at 80 ℃; for 24h;

DOI:10.1021/ol501203q

Reference yield: 75.0%

2,3-dihydro-6-methyl-1H-indole (86911-82-2) → 6-methylindoline-2,3-dione (1128-47-8)

Guidance literature:

With iodine pentoxide; In dimethyl sulfoxide; at 80 ℃;

DOI:10.1016/j.tetlet.2017.03.060

upstream raw materials:

2-hydroxyimino-N-m-tolylacetamide

oxalic acid-bis(3-tolylimidoyl)chloride

Oxalyl bromide

sulfuric acid

Downstream raw materials:

7-methyl-2H-3,1-benzoxazine-2,4(1H)-dione

4-methylanthranilic acid

methyl 4-methylanthranilate

2,3-dihydro-7-methyl-5H-as-triazino[5,6-b]indole-3-thione