4-AMINO-2-(TRIFLUOROMETHYL)PHENOL

Base Information

• Chemical Name: 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL
• CAS No.: 1535-76-8
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.126
• Mol file: 1535-76-8.mol

Synonyms:4-hydroxy-3-trifluoromethylaniline;2-Trifluormethyl-4-amino-phenol;4-amino-2-trifluoromethylphenol;

Chemical Property of 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL

Chemical Property:

• Boiling Point: 255℃
• Flash Point: 108℃
• PSA: 35.25000
• Density: 1.432
• LogP: 3.65760
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

96% ^*data from raw suppliers

4-amino-2-(trifluoromethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL

There total 4 articles about 4-AMINO-2-(TRIFLUOROMETHYL)PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-benzyloxy-3-trifluoromethyl-nitrobenzene (39062-69-6) → 4-amino-2-(trifluoromethyl)phenol (1535-76-8)

Guidance literature:

With hydrogen; 5% palladium over charcoal; In methanol; for 4h;

Reference yield: 85.0%

4-nitro-2-(trifluoromethyl)phenol (1548-61-4) → 4-amino-2-(trifluoromethyl)phenol (1535-76-8)

Guidance literature:

With water; ammonium chloride; zinc; In methanol; for 1h;

DOI:10.1016/j.jphotochem.2011.10.015

Reference yield:

1-methoxy-4-nitro-2-(trifluoromethyl)benzene (654-76-2) → 4-amino-2-(trifluoromethyl)phenol (1535-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Py*HCl / 210 °C

2: H₂ / Pd-C

With hydrogen; pyridine hydrochloride; palladium on activated charcoal;

DOI:10.1021/jo01059a515

upstream raw materials:

4-nitro-2-(trifluoromethyl)phenol

1-methoxy-4-nitro-2-(trifluoromethyl)benzene

4-benzyloxy-3-trifluoromethyl-nitrobenzene

4-nitro-2-trifluoromethyl-aniline

Downstream raw materials:

2-Chlor-3-<3-trifluormethyl-4-hydroxy-phenyl-propionsaeure

4-[(N-(t-butoxycarbonyl)piperidin-4-yl)oxy]-3-trifluoromethylbenzenamine

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