654-76-2

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C7H3F3N2O5/c8-7(9,10)17-6-2-1-4(11(13)14)3-5(6)12(15)16/h1-3H

Upstream product

• 67-56-1 methanol 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 124-41-4 sodium methylate 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 

Downstream Products

• 393-15-7 4-methoxy-3-(trifluoromethyl)aniline 
• 53903-51-8 2-trifluoromethyl-4-chlorophenol 
• 1391980-14-5 3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile 
• 1391979-79-5 N-(5-(4-chloro-2-(trifluoromethyl)phenoxy)-4-(3-cyanophenyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 178896-77-0 2-(5-methoxy-2-nitro-4-(trifluoromethyl)-phenyl)acetonitrile 
• 1010400-00-6 1-(4-iodo-2-methoxy-pyridin-3-yl)-2-(5-methoxy-2-nitro-4-trifluoromethyl-phenyl)-ethanol 
• 1010400-01-7 4-iodo-2-methoxy-3-[2-(5-methoxy-2-nitro-4-trifluoromethyl-phenyl)-vinyl]-pyridine 
• 478837-04-6 N-[4-methoxy-2-methyl-3-(trifluoromethyl)-phenyl]-2,2-dimethylpropanamide 
• 478837-02-4 N-[4-methoxy-3-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide 
• 478837-06-8 4-methoxy-2-methyl-3-(trifluoromethyl)-aniline 

Relevant academic research and scientific papers

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

Novel and selective 5-HT(2C/2B) receptor antagonists as potential anxiolytic agents: Synthesis, quantitative structure - Activity relationships, and molecular modeling of substituted 1-(3- pyridylcarbamoyl)indolines

The synthesis, biological activity, and molecular modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea 1 (SB- 206553) and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT(2C/2B) receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT(2C) receptor but disallowed at the 5-HT(2A) receptor, we have identified a number of compounds which are the most potent and selective 5-HT(2C/2B) receptor antagonists yet reported. 46 (SB-221284) was selected on the basis of its overall biological profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA analysis of these compounds produced a model with good predictive value and in addition good qualitative agreement with both our 5-HT(2C) receptor model and our proposed binding mode for this class of ligands within that model.

Process for the preparation of trifluoromethylphenols

A process for the preparation of a trifluoromethylphenol or the corresponding alkoxy compound which comprises contacting a halogenobenzotrifluoride of the formula STR1 in which X denotes halogen, R1, R2 and R3 denote hydrogen, trifluoromethyl or a substituent which promotes the replacement of X by a hydroxyl group and Y denotes hydrogen, a halogen or alkoxy, at least one of the substituents R1, R2 and R3 representing a trifluoromethyl group and at least one of them representing a substituent which promotes the replacement of the radical X by a hydroxyl group, with an excess aqueous alkali metal hydroxide in an alcoholic solution in the presence of a quaternary onium salt.