654-76-2

Basic information

• Product Name: 2-METHOXY-5-NITROBENZOTRIFLUORIDE
• Synonyms: 5-Nitro-2-methoxybenzotrifluoride;Benzene, 1-methoxy-4-nitro-2-(trifluoromethyl)-;LABOTEST-BB LT00848189;1-METHOXY-4-NITRO-2-(TRIFLUOROMETHYL)BENZENE;2-METHOXY-5-NITROBENZOTRIFLUORIDE;2-METHOXY-5-NITRO(TRIFLUOROMETHYL)BENZENE;4-NITRO-2-(TRIFLUOROMETHYL)ANISOLE;2-Trifluoromethyl-4-nitroanisole
• CAS NO: 654-76-2
• Molecular Formula: C₈H₆F₃NO₃
• Molecular Weight: 221.13
• EINECS: 211-507-3
• Product Categories: Trifluoromethylbenzene serise;Aromatic Hydrocarbons (substituted) & Derivatives;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Trifluoromethyl-benzene series
• Mol File: 654-76-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 79-81 °C(lit.)
• Boiling Point: 267.2 °C at 760 mmHg
• Flash Point: 115.4 °C
• Appearance: white to light yellow crystal powder
• Density: 1.392 g/cm³
• Vapor Pressure: 0.00217mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2129987
• CAS DataBase Reference: 2-METHOXY-5-NITROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-NITROBENZOTRIFLUORIDE(654-76-2)
• EPA Substance Registry System: 2-METHOXY-5-NITROBENZOTRIFLUORIDE(654-76-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 1759 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 654-76-2(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C7H3F3N2O5/c8-7(9,10)17-6-2-1-4(11(13)14)3-5(6)12(15)16/h1-3H

Upstream product

• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 
• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 
• 124-41-4 sodium methylate 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 67-56-1 methanol 

Downstream Products

• 178896-77-0 2-(5-methoxy-2-nitro-4-(trifluoromethyl)-phenyl)acetonitrile 
• 393-15-7 4-methoxy-3-(trifluoromethyl)aniline 
• 53903-51-8 2-trifluoromethyl-4-chlorophenol 
• 1391980-14-5 3-(2-amino-5-(4-chloro-2-(trifluoromethyl)phenoxy)thiazol-4-yl)benzonitrile 
• 1391979-79-5 N-(5-(4-chloro-2-(trifluoromethyl)phenoxy)-4-(3-cyanophenyl)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 

Relevant articles and documents

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

Process for the preparation of trifluoromethylphenols

A process for the preparation of a trifluoromethylphenol or the corresponding alkoxy compound which comprises contacting a halogenobenzotrifluoride of the formula STR1 in which X denotes halogen, R1, R2 and R3 denote hydrogen, trifluoromethyl or a substituent which promotes the replacement of X by a hydroxyl group and Y denotes hydrogen, a halogen or alkoxy, at least one of the substituents R1, R2 and R3 representing a trifluoromethyl group and at least one of them representing a substituent which promotes the replacement of the radical X by a hydroxyl group, with an excess aqueous alkali metal hydroxide in an alcoholic solution in the presence of a quaternary onium salt.