3-methoxy-4-(4-methylimidazole)benzenamine

Base Information

• Chemical Name: 3-methoxy-4-(4-methylimidazole)benzenamine
• CAS No.: 958245-18-6
• Molecular Formula: C11H13N3O
• Molecular Weight: 203.244
• Hs Code.: 2933290090
• Mol file: 958245-18-6.mol

Synonyms:3-methoxy-4-(4-methylimidazole)benzenamine;3-Methoxy-4-(4-Methyl-1H-iMidazol-1-yl)benzenaMine

Chemical Property of 3-methoxy-4-(4-methylimidazole)benzenamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 417.202°C at 760 mmHg
• Flash Point: 206.116°C
• PSA: 53.07000
• Density: 1.198g/cm³
• LogP: 2.35270
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzenamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzenamine is used in the synthesis of series of heterocycles as potent γ-secretase modulators (GSMs);Also, it is derived 4-Methylimidazole (M312990), which is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.

Technology Process of 3-methoxy-4-(4-methylimidazole)benzenamine

There total 4 articles about 3-methoxy-4-(4-methylimidazole)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole (958245-17-5) → 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (958245-18-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; Inert atmosphere of nitrogen; Cooling with ice-water;

Reference yield:

2-chloro-5-nitroanisole (1009-36-5) → 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (958245-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / dimethyl sulfoxide / 5 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / ethanol / 3.5 h / 20 °C

With potassium hydroxide; hydrogen; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide;

Reference yield:

1-fluoro-2-methoxy-4-nitrobenzene (454-16-0) → 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (958245-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Inert atmosphere; Autoclave

2: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 50 °C

With thiophene; hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide;

upstream raw materials:

1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole

1-fluoro-2-methoxy-4-nitrobenzene

2-chloro-5-nitroanisole

1-bromo-2-methoxy-4-nitrobenzene

Downstream raw materials:

1-(4-isothiocyanato-2-methoxy-phenyl)-4-methyl-1H-imidazole

[4-(4-chloro-phenyl)-thiazol-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

phenyl N-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-N-(phenoxycarbonyl)carbamate

phenyl [3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]carbamate